MGP Database

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MGP001522

Record overview

MGPD IDMGP001522
Gene ID3329
SpeciesHomo sapiens (Human)
Gene Nameheat shock 60kDa protein 1 (chaperonin)
Gene Symbol HSPD1
SynonymsHLD4; CPN60; GROEL; HSP60; HSP65; SPG13; HSP-60; HuCHA60;
Alternate names60 kDa heat shock protein, mitochondrial; 60 kDa chaperonin; P60 lymphocyte protein; chaperonin 60; heat shock protein 65; mitochondrial matrix protein P1; short heat shock protein 60 Hsp60s1;
Chromosome2
Map Location2q33.1
SummaryThis gene encodes a member of the chaperonin family. The encoded mitochondrial protein may function as a signaling molecule in the innate immune system. This protein is essential for the folding and assembly of newly imported proteins in the mitochondria. This gene is adjacent to a related family member and the region between the 2 genes functions as a bidirectional promoter. Several pseudogenes have been associated with this gene. Two transcript variants encoding the same protein have been identified for this gene. Mutations associated with this gene cause autosomal recessive spastic paraplegia 13. [provided by RefSeq, Jun 2010]
OrthologsView orthologs and multiple alignments for HSPD1

Proteins

60 kDa heat shock protein, mitochondrial
Refseq ID:NP_002147
Protein GI:31542947
UniProt ID:P10809
mRNA ID:NM_002156
Length:573
RefSeq Status:
MLRLPTVFRQMRPVSRVLAPHLTRAYAKDVKFGADARALMLQGVDLLADAVAVTMGPKGRTVIIEQSWGSPKVTKDGVTVAKSIDLKDKYKNIGAKLVQD
VANNTNEEAGDGTTTATVLARSIAKEGFEKISKGANPVEIRRGVMLAVDAVIAELKKQSKPVTTPEEIAQVATISANGDKEIGNIISDAMKKVGRKGVIT
VKDGKTLNDELEIIEGMKFDRGYISPYFINTSKGQKCEFQDAYVLLSEKKISSIQSIVPALEIANAHRKPLVIIAEDVDGEALSTLVLNRLKVGLQVVAV
KAPGFGDNRKNQLKDMAIATGGAVFGEEGLTLNLEDVQPHDLGKVGEVIVTKDDAMLLKGKGDKAQIEKRIQEIIEQLDVTTSEYEKEKLNERLAKLSDG
VAVLKVGGTSDVEVNEKKDRVTDALNATRAAVEEGIVLGGGCALLRCIPALDSLTPANEDQKIGIEIIKRTLKIPAMTIAKNAGVEGSLIVEKIMQSSSE
VGYDAMAGDFVNMVEKGIIDPTKVVRTALLDAAGVASLLTTAEVVVTEIPKEEKDPGMGAMGGMGGGMGGGMF
 
60 kDa heat shock protein, mitochondrial
Refseq ID:NP_955472
Protein GI:41399285
UniProt ID:P10809
mRNA ID:NM_199440
Length:573
RefSeq Status:
Protein sequence is identical to GI:31542947 (mRNA isoform)
 
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