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MGP001523

UniProt Annotations

Entry Information
Gene NameDnaJ (Hsp40) homolog, subfamily B, member 1
Protein EntryDNJB1_HUMAN
UniProt IDP25685
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=P25685-1; Sequence=Displayed; Name=2; IsoId=P25685-2; Sequence=VSP_056414; Note=No experimental confirmation available.;
FunctionInteracts with HSP70 and can stimulate its ATPase activity. Stimulates the association between HSC70 and HIP.
InductionBy heat shock. {ECO:0000269|PubMed:1586970}.
InteractionQ62392:Phlda1 (xeno); NbExp=2; IntAct=EBI-357034, EBI-309727;
Sequence CautionSequence=CAA44287.1; Type=Frameshift; Positions=11, 28, 81, 136; Evidence={ECO:0000305};
SimilarityContains 1 J domain. {ECO:0000255|PROSITE- ProRule:PRU00286}.
Subcellular LocationCytoplasm {ECO:0000269|PubMed:1586970}. Nucleus {ECO:0000269|PubMed:1586970}. Nucleus, nucleolus {ECO:0000269|PubMed:1586970}. Note=Translocates rapidly from the cytoplasm to the nucleus, and especially to the nucleoli, upon heat shock.
SubunitInteracts with DNAJC3. Interacts with SRPK1. {ECO:0000269|PubMed:19240134, ECO:0000269|PubMed:9920933}.
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