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MGP001540

UniProt Annotations

Entry Information
Gene Nametenascin C
Protein EntryTENA_HUMAN
UniProt IDP24821
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=6; Comment=Isoforms are produced in a tissue- and time-specific manner during development.; Name=1; IsoId=P24821-1; Sequence=Displayed; Name=2; Synonyms=HT-5; IsoId=P24821-2; Sequence=VSP_001412, VSP_001413; Name=3; IsoId=P24821-3; Sequence=VSP_001412; Name=4; Synonyms=HT-33; IsoId=P24821-4; Sequence=VSP_001413; Name=5; IsoId=P24821-5; Sequence=VSP_001414; Name=6; Synonyms=P31; IsoId=P24821-6; Sequence=VSP_001415;
DiseaseDeafness, autosomal dominant, 56 (DFNA56) [MIM:615629]: A form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. DFNA56 is characterized by progressive hearing impairment with post-lingual onset. {ECO:0000269|PubMed:23936043}. Note=The disease is caused by mutations affecting the gene represented in this entry.
FunctionExtracellular matrix protein implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity as well as neuronal regeneration. Promotes neurite outgrowth from cortical neurons grown on a monolayer of astrocytes. Ligand for integrins alpha-8/beta-1, alpha-9/beta-1, alpha-V/beta-3 and alpha-V/beta-6.
InductionBy TGFB1.
SimilarityBelongs to the tenascin family. {ECO:0000305}.
SimilarityContains 15 EGF-like domains. {ECO:0000255|PROSITE- ProRule:PRU00076}.
SimilarityContains 15 fibronectin type-III domains. {ECO:0000255|PROSITE-ProRule:PRU00316}.
SimilarityContains 1 fibrinogen C-terminal domain. {ECO:0000255|PROSITE-ProRule:PRU00739}.
Subcellular LocationSecreted, extracellular space, extracellular matrix.
SubunitHomohexamer; disulfide-linked. A homotrimer may be formed in the triple coiled-coil region and may be stabilized by disulfide rings at both ends. Two of such half-hexabrachions may be disulfide linked within the central globule. Interacts with CSPG4. {ECO:0000269|PubMed:8824254}.
Web ResourceName=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/TNCID42597ch9q33.html";
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