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MGP001549

Record overview

MGPD IDMGP001549
Gene ID3394
SpeciesHomo sapiens (Human)
Gene Nameinterferon regulatory factor 8
Gene Symbol IRF8
SynonymsICSBP; IRF-8; ICSBP1; IMD32A; IMD32B; H-ICSBP;
Alternate namesinterferon regulatory factor 8; interferon consensus sequence binding protein 1;
Chromosome16
Map Location16q24.1
SummaryInterferon consensus sequence-binding protein (ICSBP) is a transcription factor of the interferon (IFN) regulatory factor (IRF) family. Proteins of this family are composed of a conserved DNA-binding domain in the N-terminal region and a divergent C-terminal region that serves as the regulatory domain. The IRF family proteins bind to the IFN-stimulated response element (ISRE) and regulate expression of genes stimulated by type I IFNs, namely IFN-alpha and IFN-beta. IRF family proteins also control expression of IFN-alpha and IFN-beta-regulated genes that are induced by viral infection. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for IRF8

Proteins

interferon regulatory factor 8
Refseq ID:NP_002154
Protein GI:4504567
UniProt ID:Q02556
mRNA ID:NM_002163
Length:426
RefSeq Status:
MCDRNGGRRLRQWLIEQIDSSMYPGLIWENEEKSMFRIPWKHAGKQDYNQEVDASIFKAWAVFKGKFKEGDKAEPATWKTRLRCALNKSPDFEEVTDRSQ
LDISEPYKVYRIVPEEEQKCKLGVATAGCVNEVTEMECGRSEIDELIKEPSVDDYMGMIKRSPSPPEACRSQLLPDWWAQQPSTGVPLVTGYTTYDAHHS
AFSQMVISFYYGGKLVGQATTTCPEGCRLSLSQPGLPGTKLYGPEGLELVRFPPADAIPSERQRQVTRKLFGHLERGVLLHSSRQGVFVKRLCQGRVFCS
GNAVVCKGRPNKLERDEVVQVFDTSQFFRELQQFYNSQGRLPDGRVVLCFGEEFPDMAPLRSKLILVQIEQLYVRQLAEEAGKSCGAGSVMQAPEEPPPD
QVFRMFPDICASHQRSFFRENQQITV
 
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