MGP Database

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MGP001555

Record overview

MGPD IDMGP001555
Gene ID3420
SpeciesHomo sapiens (Human)
Gene Nameisocitrate dehydrogenase 3 (NAD+) beta
Gene Symbol IDH3B
SynonymsRP46; H-IDHB;
Alternate namesisocitrate dehydrogenase [NAD] subunit beta, mitochondrial; NAD(+)-specific ICDH subunit beta; NAD+-specific ICDH; NAD+-specific isocitrate dehydrogenase b subunit; NAD+-specific isocitrate dehydrogenase beta; isocitrate dehydrogenase, NAD(+)-specific, mitochondrial, beta subunit; isocitric dehydrogenase subunit beta;
Chromosome20
Map Location20p13
EC Number1.1.1.41
SummaryIsocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. NAD(+)-dependent isocitrate dehydrogenases catalyze the allosterically regulated rate-limiting step of the tricarboxylic acid cycle. Each isozyme is a heterotetramer that is composed of two alpha subunits, one beta subunit, and one gamma subunit. The protein encoded by this gene is the beta subunit of one isozyme of NAD(+)-dependent isocitrate dehydrogenase. Three alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for IDH3B

Proteins

isocitrate dehydrogenase [NAD] subunit beta, mitochondrial isoform a precursor
Refseq ID:NP_008830
Protein GI:28178821
UniProt ID:O43837
mRNA ID:NM_006899
Length:385
RefSeq Status:
MAALSGVRWLTRALVSAGNPGAWRGLSTSAAAHAASRSQAEDVRVEGSFPVTMLPGDGVGPELMHAVKEVFKAAAVPVEFQEHHLSEVQNMASEEKLEQV
LSSMKENKVAIIGKIHTPMEYKGELASYDMRLRRKLDLFANVVHVKSLPGYMTRHNNLDLVIIREQTEGEYSSLEHESARGVIECLKIVTRAKSQRIAKF
AFDYATKKGRGKVTAVHKANIMKLGDGLFLQCCEEVAELYPKIKFETMIIDNCCMQLVQNPYQFDVLVMPNLYGNIIDNLAAGLVGGAGVVPGESYSAEY
AVFETGARHPFAQAVGRNIANPTAMLLSASNMLRHLNLEYHSSMIADAVKKVIKVGKVRTRDMGGYSTTTDFIKSVIGHLQTKGS
 
transit_peptide: 1..34
calculated_mol_wt: 3408
peptide sequence: 
MAALSGVRWLTRALVSAGNPGAWRGLSTSAAAHA

mat_peptide: 35..376
product: isocitrate dehydrogenase [NAD] subunit beta, mitochondrial isoform d
calculated_mol_wt: 37830
peptide sequence: 
ASRSQAEDVRVEGSFPVTMLPGDGVGPELMHAVKEVFKAAAVPVEFQEHHLSEVQNMASEEKLEQVLSSMKENKVAIIGKIHTPMEYKGELASYDMRLRR
KLDLFANVVHVKSLPGYMTRHNNLDLVIIREQTEGEYSSLEHESARGVIECLKIVTRAKSQRIAKFAFDYATKKGRGKVTAVHKANIMKLGDGLFLQCCE
EVAELYPKIKFETMIIDNCCMQLVQNPYQFDVLVMPNLYGNIIDNLAAGLVGGAGVVPGESYSAEYAVFETGARHPFAQAVGRNIANPTAMLLSASNMLR
HLNLEYHSSMIADAVKKVIKVGKIPSAVPSFLLHPLPFSWAI

transit_peptide: 1..34
inference: non-experimental evidence, no additional details recorded
note: Mitochondrion (By similarity); propagated from UniProtKB/Swiss-Prot (O43837.2)
calculated_mol_wt: 3408
peptide sequence: 
MAALSGVRWLTRALVSAGNPGAWRGLSTSAAAHA

mat_peptide: 35..385
product: Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (O43837.2)
calculated_mol_wt: 38794
peptide sequence: 
ASRSQAEDVRVEGSFPVTMLPGDGVGPELMHAVKEVFKAAAVPVEFQEHHLSEVQNMASEEKLEQVLSSMKENKVAIIGKIHTPMEYKGELASYDMRLRR
KLDLFANVVHVKSLPGYMTRHNNLDLVIIREQTEGEYSSLEHESARGVIECLKIVTRAKSQRIAKFAFDYATKKGRGKVTAVHKANIMKLGDGLFLQCCE
EVAELYPKIKFETMIIDNCCMQLVQNPYQFDVLVMPNLYGNIIDNLAAGLVGGAGVVPGESYSAEYAVFETGARHPFAQAVGRNIANPTAMLLSASNMLR
HLNLEYHSSMIADAVKKVIKVGKVRTRDMGGYSTTTDFIKSVIGHLQTKGS
 
isocitrate dehydrogenase [NAD] subunit beta, mitochondrial isoform b precursor
Refseq ID:NP_777280
Protein GI:28178816
UniProt ID:O43837
mRNA ID:NM_174855
Length:383
RefSeq Status:
MAALSGVRWLTRALVSAGNPGAWRGLSTSAAAHAASRSQAEDVRVEGSFPVTMLPGDGVGPELMHAVKEVFKAAAVPVEFQEHHLSEVQNMASEEKLEQV
LSSMKENKVAIIGKIHTPMEYKGELASYDMRLRRKLDLFANVVHVKSLPGYMTRHNNLDLVIIREQTEGEYSSLEHESARGVIECLKIVTRAKSQRIAKF
AFDYATKKGRGKVTAVHKANIMKLGDGLFLQCCEEVAELYPKIKFETMIIDNCCMQLVQNPYQFDVLVMPNLYGNIIDNLAAGLVGGAGVVPGESYSAEY
AVFETGARHPFAQAVGRNIANPTAMLLSASNMLRHLNLEYHSSMIADAVKKVIKVGKVRTSDMGGYATCHDFTEAVIAALPHP
 
transit_peptide: 1..34
calculated_mol_wt: 3408
peptide sequence: 
MAALSGVRWLTRALVSAGNPGAWRGLSTSAAAHA

mat_peptide: 35..376
product: isocitrate dehydrogenase [NAD] subunit beta, mitochondrial isoform d
calculated_mol_wt: 37830
peptide sequence: 
ASRSQAEDVRVEGSFPVTMLPGDGVGPELMHAVKEVFKAAAVPVEFQEHHLSEVQNMASEEKLEQVLSSMKENKVAIIGKIHTPMEYKGELASYDMRLRR
KLDLFANVVHVKSLPGYMTRHNNLDLVIIREQTEGEYSSLEHESARGVIECLKIVTRAKSQRIAKFAFDYATKKGRGKVTAVHKANIMKLGDGLFLQCCE
EVAELYPKIKFETMIIDNCCMQLVQNPYQFDVLVMPNLYGNIIDNLAAGLVGGAGVVPGESYSAEYAVFETGARHPFAQAVGRNIANPTAMLLSASNMLR
HLNLEYHSSMIADAVKKVIKVGKIPSAVPSFLLHPLPFSWAI

transit_peptide: 1..34
inference: non-experimental evidence, no additional details recorded
note: Mitochondrion (By similarity); propagated from UniProtKB/Swiss-Prot (O43837.2)
calculated_mol_wt: 3408
peptide sequence: 
MAALSGVRWLTRALVSAGNPGAWRGLSTSAAAHA

mat_peptide: 35..385
product: Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (O43837.2)
calculated_mol_wt: 38794
peptide sequence: 
ASRSQAEDVRVEGSFPVTMLPGDGVGPELMHAVKEVFKAAAVPVEFQEHHLSEVQNMASEEKLEQVLSSMKENKVAIIGKIHTPMEYKGELASYDMRLRR
KLDLFANVVHVKSLPGYMTRHNNLDLVIIREQTEGEYSSLEHESARGVIECLKIVTRAKSQRIAKFAFDYATKKGRGKVTAVHKANIMKLGDGLFLQCCE
EVAELYPKIKFETMIIDNCCMQLVQNPYQFDVLVMPNLYGNIIDNLAAGLVGGAGVVPGESYSAEYAVFETGARHPFAQAVGRNIANPTAMLLSASNMLR
HLNLEYHSSMIADAVKKVIKVGKVRTRDMGGYSTTTDFIKSVIGHLQTKGS

transit_peptide: 1..34
calculated_mol_wt: 3408
peptide sequence: 
MAALSGVRWLTRALVSAGNPGAWRGLSTSAAAHA

mat_peptide: 35..383
product: isocitrate dehydrogenase [NAD] subunit beta, mitochondrial isoform b
calculated_mol_wt: 38498
peptide sequence: 
ASRSQAEDVRVEGSFPVTMLPGDGVGPELMHAVKEVFKAAAVPVEFQEHHLSEVQNMASEEKLEQVLSSMKENKVAIIGKIHTPMEYKGELASYDMRLRR
KLDLFANVVHVKSLPGYMTRHNNLDLVIIREQTEGEYSSLEHESARGVIECLKIVTRAKSQRIAKFAFDYATKKGRGKVTAVHKANIMKLGDGLFLQCCE
EVAELYPKIKFETMIIDNCCMQLVQNPYQFDVLVMPNLYGNIIDNLAAGLVGGAGVVPGESYSAEYAVFETGARHPFAQAVGRNIANPTAMLLSASNMLR
HLNLEYHSSMIADAVKKVIKVGKVRTSDMGGYATCHDFTEAVIAALPHP
 
isocitrate dehydrogenase [NAD] subunit beta, mitochondrial isoform d
Refseq ID:NP_001245313
Protein GI:385648280
UniProt ID:
mRNA ID:NM_001258384
Length:376
RefSeq Status:
MAALSGVRWLTRALVSAGNPGAWRGLSTSAAAHAASRSQAEDVRVEGSFPVTMLPGDGVGPELMHAVKEVFKAAAVPVEFQEHHLSEVQNMASEEKLEQV
LSSMKENKVAIIGKIHTPMEYKGELASYDMRLRRKLDLFANVVHVKSLPGYMTRHNNLDLVIIREQTEGEYSSLEHESARGVIECLKIVTRAKSQRIAKF
AFDYATKKGRGKVTAVHKANIMKLGDGLFLQCCEEVAELYPKIKFETMIIDNCCMQLVQNPYQFDVLVMPNLYGNIIDNLAAGLVGGAGVVPGESYSAEY
AVFETGARHPFAQAVGRNIANPTAMLLSASNMLRHLNLEYHSSMIADAVKKVIKVGKIPSAVPSFLLHPLPFSWAI
 
transit_peptide: 1..34
calculated_mol_wt: 3408
peptide sequence: 
MAALSGVRWLTRALVSAGNPGAWRGLSTSAAAHA

mat_peptide: 35..376
product: isocitrate dehydrogenase [NAD] subunit beta, mitochondrial isoform d
calculated_mol_wt: 37830
peptide sequence: 
ASRSQAEDVRVEGSFPVTMLPGDGVGPELMHAVKEVFKAAAVPVEFQEHHLSEVQNMASEEKLEQVLSSMKENKVAIIGKIHTPMEYKGELASYDMRLRR
KLDLFANVVHVKSLPGYMTRHNNLDLVIIREQTEGEYSSLEHESARGVIECLKIVTRAKSQRIAKFAFDYATKKGRGKVTAVHKANIMKLGDGLFLQCCE
EVAELYPKIKFETMIIDNCCMQLVQNPYQFDVLVMPNLYGNIIDNLAAGLVGGAGVVPGESYSAEYAVFETGARHPFAQAVGRNIANPTAMLLSASNMLR
HLNLEYHSSMIADAVKKVIKVGKIPSAVPSFLLHPLPFSWAI
 
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