MGP Database

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MGP001561

Ontology/Pathway Information

Entrez Gene ID3428
Gene Nameinterferon, gamma-inducible protein 16
Gene Symbol IFI16
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005737 IDA:HPACcytoplasm
GO:0005829 TAS:ReactomeCcytosol
GO:0016020 IDA:UniProtKBCmembrane
GO:0016607 IDA:MGICnuclear speck
GO:0005730 IDA:HPACnucleolus
GO:0005654 IDA:MGICnucleoplasm
GO:0005634 IDA:UniProtKBCnucleus
GO:0001047 IDA:UniProtKBFcore promoter binding
GO:0003690 IDA:UniProtKBFdouble-stranded DNA binding
GO:0042802 IPI:IntActFidentical protein binding
GO:0044822 IDA:UniProtKBFpoly(A) RNA binding
GO:0000978 IDA:NTNU_SBFRNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001078 IDA:NTNU_SBFRNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0008134 IDA:UniProtKBFtranscription factor binding
GO:0097202 IMP:UniProtKBPactivation of cysteine-type endopeptidase activity
GO:0002218 IDA:UniProtKBPactivation of innate immune response
GO:0006914 IEA:UniProtKB-KWPautophagy
GO:0008283 NAS:UniProtKBPcell proliferation
GO:0042149 IDA:UniProtKBPcellular response to glucose starvation
GO:0071479 IDA:UniProtKBPcellular response to ionizing radiation
GO:0051607 IMP:UniProtKBPdefense response to virus
GO:0030097 NAS:UniProtKBPhemopoiesis
GO:0006954 IEA:UniProtKB-KWPinflammatory response
GO:0045087 TAS:ReactomePinnate immune response
GO:0072332 IMP:UniProtKBPintrinsic apoptotic signaling pathway by p53 class mediator
GO:0042771 IDA:MGIPintrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:0030224 IDA:UniProtKBPmonocyte differentiation
GO:0030099 NAS:UniProtKBPmyeloid cell differentiation
GO:2000117 IDA:UniProtKBPnegative regulation of cysteine-type endopeptidase activity
GO:0043392 IDA:UniProtKBPnegative regulation of DNA binding
GO:0045824 IDA:UniProtKBPnegative regulation of innate immune response
GO:0045892 IDA:UniProtKBPnegative regulation of transcription, DNA-templated
GO:0000122 IDA:UniProtKBPnegative regulation of transcription from RNA polymerase II promoter
GO:0045071 IDA:UniProtKBPnegative regulation of viral genome replication
GO:0001819 TAS:UniProtKBPpositive regulation of cytokine production
GO:0032731 IDA:UniProtKBPpositive regulation of interleukin-1 beta production
GO:0045944 IDA:UniProtKBPpositive regulation of transcription from RNA polymerase II promoter
GO:0032481 TAS:ReactomePpositive regulation of type I interferon production
GO:0010506 IEP:UniProtKBPregulation of autophagy
GO:0040029 IMP:UniProtKBPregulation of gene expression, epigenetic
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_118823Cytosolic sensors of pathogen-associated DNA
REACT_6900Immune System
REACT_6802Innate Immune System
REACT_163993IRF3-mediated induction of type I IFN
REACT_147841STING mediated induction of host immune responses
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