MGP Database

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MGP001562

UniProt Annotations

Entry Information
Gene Nameinterferon, alpha-inducible protein 27
Protein Entry
UniProt ID
SpeciesHuman
Comments
Comment typeDescription
FunctionPromotes cell death. Mediates IFN-induced apoptosis characterized by a rapid and robust release of cytochrome C from the mitochondria and activation of BAX and caspases 2, 3, 6, 8 and 9. {ECO:0000269|PubMed:18330707}.
InductionUp-regulated by interferons. {ECO:0000269|PubMed:18330707}.
SimilarityBelongs to the IFI6/IFI27 family. {ECO:0000305}.
Subcellular LocationMitochondrion {ECO:0000269|PubMed:18330707}. Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
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