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MGP001566

UniProt Annotations

Entry Information
Gene Nameinterferon-induced protein with tetratricopeptide repeats 3
Protein Entry
UniProt ID
SpeciesHuman
Comments
Comment typeDescription
FunctionIFN-induced antiviral protein which acts as an inhibitor of cellular as well as viral processes, cell migration, proliferation, signaling, and viral replication. Enhances MAVS- mediated host antiviral responses by serving as an adapter bridging TBK1 to MAVS which leads to the activation of TBK1 and phosphorylation of IRF3 and phosphorylated IRF3 translocates into nucleus to promote antiviral gene transcription. Exihibits an antiproliferative activity via the up-regulation of cell cycle negative regulators CDKN1A/p21 and CDKN1B/p27. Normally, CDKN1B/p27 turnover is regulated by COPS5, which binds CDKN1B/p27 in the nucleus and exports it to the cytoplasm for ubiquitin- dependent degradation. IFIT3 sequesters COPS5 in the cytoplasm, thereby increasing nuclear CDKN1B/p27 protein levels. Upregulates CDKN1A/p21 by downregulating MYC, a repressor of CDKN1A/p21. Can negatively regulate the apoptotic effects of IFIT2. {ECO:0000269|PubMed:17050680, ECO:0000269|PubMed:20686046, ECO:0000269|PubMed:21190939, ECO:0000269|PubMed:21642987, ECO:0000269|PubMed:21813773}.
InductionBy type I interferons, dsRNAs and viruses. {ECO:0000269|PubMed:17050680}.
InteractionSelf; NbExp=3; IntAct=EBI-745127, EBI-745127; Q16543:CDC37; NbExp=4; IntAct=EBI-745127, EBI-295634; P09914:IFIT1; NbExp=5; IntAct=EBI-745127, EBI-745117; P09913:IFIT2; NbExp=4; IntAct=EBI-745127, EBI-3507167;
SimilarityBelongs to the IFIT family. {ECO:0000305}.
SimilarityContains 8 TPR repeats. {ECO:0000255|PROSITE- ProRule:PRU00339}.
Subcellular LocationCytoplasm. Mitochondrion.
SubunitComponent of an interferon-dependent multiprotein complex, at least composed of IFIT1, IFIT2 and IFIT3. Interacts with IFIT1 and IFIT2. Interacts (via N-terminus) with MAVS, TBK1, TRAF6 and DDX58. Interacts with COPS5. {ECO:0000269|PubMed:17050680, ECO:0000269|PubMed:21190939, ECO:0000269|PubMed:21642987, ECO:0000269|PubMed:21813773}.
Tissue SpecificityExpression significantly higher in peripheral blood mononuclear cells (PBMCs) and monocytes from systemic lupus erythematosus (SLE) patients than in those from healthy individuals (at protein level). Spleen, lung, leukocytes, lymph nodes, placenta, bone marrow and fetal liver. {ECO:0000269|PubMed:18706081}.
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