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MGP001585

Record overview

MGPD IDMGP001585
Gene ID3479
SpeciesHomo sapiens (Human)
Gene Nameinsulin-like growth factor 1 (somatomedin C)
Gene Symbol IGF1
SynonymsIGFI; IGF-I; IGF1A;
Alternate namesinsulin-like growth factor I; IGF-IA; IGF-IB; MGF; insulin-like growth factor IA; insulin-like growth factor IB; mechano growth factor; somatomedin-C;
Chromosome12
Map Location12q23.2
SummaryThe protein encoded by this gene is similar to insulin in function and structure and is a member of a family of proteins involved in mediating growth and development. The encoded protein is processed from a precursor, bound by a specific receptor, and secreted. Defects in this gene are a cause of insulin-like growth factor I deficiency. Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2009]
OrthologsView orthologs and multiple alignments for IGF1

Proteins

insulin-like growth factor I isoform 1 preproprotein
Refseq ID:NP_001104753
Protein GI:163659899
UniProt ID:Q13429
mRNA ID:NM_001111283
Length:158
RefSeq Status:
MGKISSLPTQLFKCCFCDFLKVKMHTMSSSHLFYLALCLLTFTSSATAGPETLCGAELVDALQFVCGDRGFYFNKPTGYGSSSRRAPQTGIVDECCFRSC
DLRRLEMYCAPLKPAKSARSVRAQRHTDMPKTQKYQPPSTNKNTKSQRRKGSTFEERK
 
sig_peptide: 1..21
inference: non-experimental evidence, no additional details recorded
note: Potential; propagated from UniProtKB/Swiss-Prot (P05019.1)
calculated_mol_wt: 2410
peptide sequence: 
MGKISSLPTQLFKCCFCDFLK

mat_peptide: 49..118
product: insulin-like growth factor I isoform 1
calculated_mol_wt: 7655
peptide sequence: 
GPETLCGAELVDALQFVCGDRGFYFNKPTGYGSSSRRAPQTGIVDECCFRSCDLRRLEMYCAPLKPAKSA
 
insulin-like growth factor I isoform 2 preproprotein
Refseq ID:NP_001104754
Protein GI:163659901
UniProt ID:P05019
mRNA ID:NM_001111284
Length:137
RefSeq Status:
MITPTVKMHTMSSSHLFYLALCLLTFTSSATAGPETLCGAELVDALQFVCGDRGFYFNKPTGYGSSSRRAPQTGIVDECCFRSCDLRRLEMYCAPLKPAK
SARSVRAQRHTDMPKTQKEVHLKNASRGSAGNKNYRM
 
sig_peptide: 1..21
inference: non-experimental evidence, no additional details recorded
note: Potential; propagated from UniProtKB/Swiss-Prot (P05019.1)
calculated_mol_wt: 2410
peptide sequence: 
MGKISSLPTQLFKCCFCDFLK

mat_peptide: 49..118
product: insulin-like growth factor I isoform 1
calculated_mol_wt: 7655
peptide sequence: 
GPETLCGAELVDALQFVCGDRGFYFNKPTGYGSSSRRAPQTGIVDECCFRSCDLRRLEMYCAPLKPAKSA

sig_peptide: 1..21
inference: non-experimental evidence, no additional details recorded
note: Potential; propagated from UniProtKB/Swiss-Prot (P05019.1)
calculated_mol_wt: 2410
peptide sequence: 
MGKISSLPTQLFKCCFCDFLK

mat_peptide: 49..118
product: insulin-like growth factor I isoform 3
calculated_mol_wt: 7655
peptide sequence: 
GPETLCGAELVDALQFVCGDRGFYFNKPTGYGSSSRRAPQTGIVDECCFRSCDLRRLEMYCAPLKPAKSA

sig_peptide: 1..32
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 3505
peptide sequence: 
MITPTVKMHTMSSSHLFYLALCLLTFTSSATA

mat_peptide: 33..102
product: insulin-like growth factor I isoform 2
calculated_mol_wt: 7655
peptide sequence: 
GPETLCGAELVDALQFVCGDRGFYFNKPTGYGSSSRRAPQTGIVDECCFRSCDLRRLEMYCAPLKPAKSA
 
insulin-like growth factor I isoform 3 preproprotein
Refseq ID:NP_001104755
Protein GI:163659903
UniProt ID:P05019
mRNA ID:NM_001111285
Length:195
RefSeq Status:
MGKISSLPTQLFKCCFCDFLKVKMHTMSSSHLFYLALCLLTFTSSATAGPETLCGAELVDALQFVCGDRGFYFNKPTGYGSSSRRAPQTGIVDECCFRSC
DLRRLEMYCAPLKPAKSARSVRAQRHTDMPKTQKYQPPSTNKNTKSQRRKGWPKTHPGGEQKEGTEASLQIRGKKKEQRREIGSRNAECRGKKGK
 
sig_peptide: 1..21
inference: non-experimental evidence, no additional details recorded
note: Potential; propagated from UniProtKB/Swiss-Prot (P05019.1)
calculated_mol_wt: 2410
peptide sequence: 
MGKISSLPTQLFKCCFCDFLK

mat_peptide: 49..118
product: insulin-like growth factor I isoform 1
calculated_mol_wt: 7655
peptide sequence: 
GPETLCGAELVDALQFVCGDRGFYFNKPTGYGSSSRRAPQTGIVDECCFRSCDLRRLEMYCAPLKPAKSA

sig_peptide: 1..21
inference: non-experimental evidence, no additional details recorded
note: Potential; propagated from UniProtKB/Swiss-Prot (P05019.1)
calculated_mol_wt: 2410
peptide sequence: 
MGKISSLPTQLFKCCFCDFLK

mat_peptide: 49..118
product: insulin-like growth factor I isoform 3
calculated_mol_wt: 7655
peptide sequence: 
GPETLCGAELVDALQFVCGDRGFYFNKPTGYGSSSRRAPQTGIVDECCFRSCDLRRLEMYCAPLKPAKSA
 
insulin-like growth factor I isoform 4 preproprotein
Refseq ID:NP_000609
Protein GI:11024682
UniProt ID:P05019
mRNA ID:NM_000618
Length:153
RefSeq Status:
MGKISSLPTQLFKCCFCDFLKVKMHTMSSSHLFYLALCLLTFTSSATAGPETLCGAELVDALQFVCGDRGFYFNKPTGYGSSSRRAPQTGIVDECCFRSC
DLRRLEMYCAPLKPAKSARSVRAQRHTDMPKTQKEVHLKNASRGSAGNKNYRM
 
sig_peptide: 1..21
inference: non-experimental evidence, no additional details recorded
note: Potential; propagated from UniProtKB/Swiss-Prot (P05019.1)
calculated_mol_wt: 2410
peptide sequence: 
MGKISSLPTQLFKCCFCDFLK

mat_peptide: 49..118
product: insulin-like growth factor I isoform 1
calculated_mol_wt: 7655
peptide sequence: 
GPETLCGAELVDALQFVCGDRGFYFNKPTGYGSSSRRAPQTGIVDECCFRSCDLRRLEMYCAPLKPAKSA

sig_peptide: 1..21
inference: non-experimental evidence, no additional details recorded
note: Potential; propagated from UniProtKB/Swiss-Prot (P05019.1)
calculated_mol_wt: 2410
peptide sequence: 
MGKISSLPTQLFKCCFCDFLK

mat_peptide: 49..118
product: insulin-like growth factor I isoform 3
calculated_mol_wt: 7655
peptide sequence: 
GPETLCGAELVDALQFVCGDRGFYFNKPTGYGSSSRRAPQTGIVDECCFRSCDLRRLEMYCAPLKPAKSA

sig_peptide: 1..32
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 3505
peptide sequence: 
MITPTVKMHTMSSSHLFYLALCLLTFTSSATA

mat_peptide: 33..102
product: insulin-like growth factor I isoform 2
calculated_mol_wt: 7655
peptide sequence: 
GPETLCGAELVDALQFVCGDRGFYFNKPTGYGSSSRRAPQTGIVDECCFRSCDLRRLEMYCAPLKPAKSA

sig_peptide: 1..21
inference: non-experimental evidence, no additional details recorded
note: Potential; propagated from UniProtKB/Swiss-Prot (P05019.1)
calculated_mol_wt: 2410
peptide sequence: 
MGKISSLPTQLFKCCFCDFLK

mat_peptide: 49..118
product: insulin-like growth factor I isoform 4
calculated_mol_wt: 7655
peptide sequence: 
GPETLCGAELVDALQFVCGDRGFYFNKPTGYGSSSRRAPQTGIVDECCFRSCDLRRLEMYCAPLKPAKSA
 
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