MGP Database

MGP001586

Ontology/Pathway Information

Entrez Gene ID	3480
Gene Name	insulin-like growth factor 1 receptor
Gene Symbol	IGF1R
Species	Homo sapiens

Gene Ontology (GO Annotations)

GO ID	Source	Type	Description
GO:0005901	IEA:Ensembl	C	caveola
GO:0005887	IC:UniProtKB	C	integral component of plasma membrane
GO:0043231	IDA:BHF-UCL	C	intracellular membrane-bounded organelle
GO:0016020	IDA:BHF-UCL	C	membrane
GO:0043005	IEA:Ensembl	C	neuron projection
GO:0005886	TAS:Reactome	C	plasma membrane
GO:0043235	IDA:MGI	C	receptor complex
GO:0005524	IEA:UniProtKB-KW	F	ATP binding
GO:0042802	IPI:IntAct	F	identical protein binding
GO:0043559	IPI:BHF-UCL	F	insulin binding
GO:0005010	IDA:UniProtKB	F	insulin-like growth factor-activated receptor activity
GO:0005520	IDA:UniProtKB	F	insulin-like growth factor binding
GO:0031994	IPI:BHF-UCL	F	insulin-like growth factor I binding
GO:0005158	IDA:BHF-UCL	F	insulin receptor binding
GO:0043560	IPI:UniProtKB	F	insulin receptor substrate binding
GO:0043548	IPI:UniProtKB	F	phosphatidylinositol 3-kinase binding
GO:0004713	IDA:UniProtKB	F	protein tyrosine kinase activity
GO:0007409	IEA:Ensembl	P	axonogenesis
GO:0007420	IEA:Ensembl	P	brain development
GO:0008544	IEA:Ensembl	P	epidermis development
GO:0030010	IEA:Ensembl	P	establishment of cell polarity
GO:0031017	IEA:Ensembl	P	exocrine pancreas development
GO:0006955	IMP:BHF-UCL	P	immune response
GO:0051389	IDA:UniProtKB	P	inactivation of MAPKK activity
GO:0048009	IDA:UniProtKB	P	insulin-like growth factor receptor signaling pathway
GO:0008286	TAS:ProtInc	P	insulin receptor signaling pathway
GO:0030238	IEA:Ensembl	P	male sex determination
GO:0030879	IEA:Ensembl	P	mammary gland development
GO:0043066	IDA:UniProtKB	P	negative regulation of apoptotic process
GO:0010656	IEA:Ensembl	P	negative regulation of muscle cell apoptotic process
GO:0051898	IEA:Ensembl	P	negative regulation of protein kinase B signaling
GO:0043433	IEA:Ensembl	P	negative regulation of sequence-specific DNA binding transcription factor activity
GO:0038083	IMP:MGI	P	peptidyl-tyrosine autophosphorylation
GO:0014065	IC:BHF-UCL	P	phosphatidylinositol 3-kinase signaling
GO:0048015	IDA:BHF-UCL	P	phosphatidylinositol-mediated signaling
GO:0030335	IMP:BHF-UCL	P	positive regulation of cell migration
GO:0008284	TAS:ProtInc	P	positive regulation of cell proliferation
GO:0032467	IEA:Ensembl	P	positive regulation of cytokinesis
GO:0045740	IMP:BHF-UCL	P	positive regulation of DNA replication
GO:0043410	IEA:Ensembl	P	positive regulation of MAPK cascade
GO:0045840	IEA:Ensembl	P	positive regulation of mitosis
GO:0051897	IEA:Ensembl	P	positive regulation of protein kinase B signaling
GO:0090031	IEA:Ensembl	P	positive regulation of steroid hormone biosynthetic process
GO:0060740	IEA:Ensembl	P	prostate gland epithelium morphogenesis
GO:0046777	IDA:UniProtKB	P	protein autophosphorylation
GO:0051291	IEA:Ensembl	P	protein heterooligomerization
GO:0051262	IDA:UniProtKB	P	protein tetramerization
GO:0046328	IDA:UniProtKB	P	regulation of JNK cascade
GO:0033197	IEA:Ensembl	P	response to vitamin E
GO:0007165	TAS:ProtInc	P	signal transduction

REACTOME Pathway Links

REACTOME Pathway ID	Description
REACT_150210	IGF1R signaling cascade
REACT_150203	IRS-related events triggered by IGF1R
REACT_150139	SHC-related events triggered by IGF1R
REACT_150359	Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
REACT_111102	Signal Transduction