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MGP001590

Record overview

MGPD IDMGP001590
Gene ID3484
SpeciesHomo sapiens (Human)
Gene Nameinsulin-like growth factor binding protein 1
Gene Symbol IGFBP1
SynonymsAFBP; IBP1; PP12; IGF-BP25; hIGFBP-1;
Alternate namesinsulin-like growth factor-binding protein 1; IBP-1; IGF-binding protein 1; IGFBP-1; alpha-pregnancy-associated endometrial globulin; amniotic fluid binding protein; binding protein-25; binding protein-26; binding protein-28; growth hormone independent-binding protein; placental protein 12;
Chromosome7
Map Location7p12.3
SummaryThis gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein binds both insulin-like growth factors (IGFs) I and II and circulates in the plasma. Binding of this protein prolongs the half-life of the IGFs and alters their interaction with cell surface receptors. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for IGFBP1

Proteins

insulin-like growth factor-binding protein 1 precursor
Refseq ID:NP_000587
Protein GI:4504615
UniProt ID:P08833
mRNA ID:NM_000596
Length:259
RefSeq Status:
MSEVPVARVWLVLLLLTVQVGVTAGAPWQCAPCSAEKLALCPPVSASCSEVTRSAGCGCCPMCALPLGAACGVATARCARGLSCRALPGEQQPLHALTRG
QGACVQESDASAPHAAEAGSPESPESTEITEEELLDNFHLMAPSEEDHSILWDAISTYDGSKALHVTNIKKWKEPCRIELYRVVESLAKAQETSGEEISK
FYLPNCNKNGFYHSRQCETSMDGEAGLCWCVYPWNGKRIPGSPEIRGDPNCQIYFNVQN
 
sig_peptide: 1..25
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2651
peptide sequence: 
MSEVPVARVWLVLLLLTVQVGVTAG

mat_peptide: 26..259
product: insulin-like growth factor-binding protein 1
calculated_mol_wt: 25271
peptide sequence: 
APWQCAPCSAEKLALCPPVSASCSEVTRSAGCGCCPMCALPLGAACGVATARCARGLSCRALPGEQQPLHALTRGQGACVQESDASAPHAAEAGSPESPE
STEITEEELLDNFHLMAPSEEDHSILWDAISTYDGSKALHVTNIKKWKEPCRIELYRVVESLAKAQETSGEEISKFYLPNCNKNGFYHSRQCETSMDGEA
GLCWCVYPWNGKRIPGSPEIRGDPNCQIYFNVQN
 
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