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MGP001595

UniProt Annotations

Entry Information
Gene Nameinsulin-like growth factor binding protein 6
Protein EntryIBP6_HUMAN
UniProt IDP24592
SpeciesHuman
Comments
Comment typeDescription
FunctionIGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.
PtmO-linked glycans consist of hexose (probably Gal), N- acetylhexosamine (probably GalNAc) and sialic acid residues. O- glycosylated with core 1 or possibly core 8 glycans. O- glycosylated on one site only in the region AA 143-168 in cerebrospinal fluid. {ECO:0000269|PubMed:19838169, ECO:0000269|PubMed:9572875}.
SimilarityContains 1 IGFBP N-terminal domain. {ECO:0000255|PROSITE-ProRule:PRU00653}.
SimilarityContains 1 thyroglobulin type-1 domain. {ECO:0000255|PROSITE-ProRule:PRU00500}.
Subcellular LocationSecreted.
Web ResourceName=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/igfbp6/";
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