MGP Database

MGP001596

Record overview

MGPD ID	MGP001596
Gene ID	3490
Species	Homo sapiens (Human)
Gene Name	insulin-like growth factor binding protein 7
Gene Symbol	IGFBP7
Synonyms	AGM; PSF; TAF; FSTL2; IBP-7; MAC25; IGFBP-7; RAMSVPS; IGFBP-7v; IGFBPRP1;
Alternate names	insulin-like growth factor-binding protein 7; IGF-binding protein 7; IGFBP-rP1; PGI2-stimulating factor; angiomodulin; prostacyclin-stimulating factor; tumor-derived adhesion factor;
Chromosome	4
Map Location	4q12
Summary	This gene encodes a member of the insulin-like growth factor (IGF)-binding protein (IGFBP) family. IGFBPs bind IGFs with high affinity, and regulate IGF availability in body fluids and tissues and modulate IGF binding to its receptors. This protein binds IGF-I and IGF-II with relatively low affinity, and belongs to a subfamily of low-affinity IGFBPs. It also stimulates prostacyclin production and cell adhesion. Alternatively spliced transcript variants encoding different isoforms have been described for this gene, and one variant has been associated with retinal arterial macroaneurysm (PMID:21835307). [provided by RefSeq, Dec 2011]
Orthologs	View orthologs and multiple alignments for IGFBP7

Proteins

insulin-like growth factor-binding protein 7 isoform 1 precursor

Refseq ID:	NP_001544
Protein GI:	4504619
UniProt ID:	Q16270
mRNA ID:	NM_001553
Length:	282
RefSeq Status:

`MERPSLRALLLGAAGLLLLLLPLSSSSSSDTCGPCEPASCPPLPPLGCLLGETRDACGCCPMCARGEGEPCGGGGAGRGYCAPGMECVKSRKRRKGKAGA AAGGPGVSGVCVCKSRYPVCGSDGTTYPSGCQLRAASQRAESRGEKAITQVSKGTCEQGPSIVTPPKDIWNVTGAQVYLSCEVIGIPTPVLIWNKVKRGH YGVQRTELLPGDRDNLAIQTRGGPEKHEVTGWVLVSPLSKEDAGEYECHASNSQGQASASAKITVVDALHEIPVKKGEGAEL`

sig_peptide: 1..26
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2705
peptide sequence: 
MERPSLRALLLGAAGLLLLLLPLSSS

sig_peptide: 1..26
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2705
peptide sequence: 
MERPSLRALLLGAAGLLLLLLPLSSS

mat_peptide: 27..282
product: Insulin-like growth factor-binding protein 7
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (Q16270.1)
calculated_mol_wt: 26443
peptide sequence: 
SSSDTCGPCEPASCPPLPPLGCLLGETRDACGCCPMCARGEGEPCGGGGAGRGYCAPGMECVKSRKRRKGKAGAAAGGPGVSGVCVCKSRYPVCGSDGTT
YPSGCQLRAASQRAESRGEKAITQVSKGTCEQGPSIVTPPKDIWNVTGAQVYLSCEVIGIPTPVLIWNKVKRGHYGVQRTELLPGDRDNLAIQTRGGPEK
HEVTGWVLVSPLSKEDAGEYECHASNSQGQASASAKITVVDALHEIPVKKGEGAEL

insulin-like growth factor-binding protein 7 isoform 2 precursor

Refseq ID:	NP_001240764
Protein GI:	359465608
UniProt ID:	Q16270
mRNA ID:	NM_001253835
Length:	279
RefSeq Status:

`MERPSLRALLLGAAGLLLLLLPLSSSSSSDTCGPCEPASCPPLPPLGCLLGETRDACGCCPMCARGEGEPCGGGGAGRGYCAPGMECVKSRKRRKGKAGA AAGGPGVSGVCVCKSRYPVCGSDGTTYPSGCQLRAASQRAESRGEKAITQVSKGTCEQGPSIVTPPKDIWNVTGAQVYLSCEVIGIPTPVLIWNKVKRGH YGVQRTELLPGDRDNLAIQTRGGPEKHEVTGWVLVSPLSKEDAGEYECHASNSQGQASASAKITVVDALHEIPVKKGTQ`

`sig_peptide: 1..26 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 2705 peptide sequence: MERPSLRALLLGAAGLLLLLLPLSSS`