MGP Database

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MGP001597

Ontology/Pathway Information

Entrez Gene ID3516
Gene Namerecombination signal binding protein for immunoglobulin kappa J region
Gene Symbol RBPJ
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005737 IDA:UniProtKBCcytoplasm
GO:0002193 IDA:UniProtKBCMAML1-RBP-Jkappa- ICN1 complex
GO:0005730 IDA:UniProtKBCnucleolus
GO:0005654 TAS:ReactomeCnucleoplasm
GO:0005634 IDA:UniProtKBCnucleus
GO:0005667 IEA:EnsemblCtranscription factor complex
GO:0003682 IEA:EnsemblFchromatin binding
GO:0003677 TAS:UniProtKBFDNA binding
GO:0000150 NAS:UniProtKBFrecombinase activity
GO:0000978 IEA:InterProFRNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077 IDA:MGIFRNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0000979 IEA:EnsemblFRNA polymerase II core promoter sequence-specific DNA binding
GO:0001103 IPI:BHF-UCLFRNA polymerase II repressing transcription factor binding
GO:0003700 TAS:UniProtKBFsequence-specific DNA binding transcription factor activity
GO:0001525 ISS:BHF-UCLPangiogenesis
GO:0060844 IEA:EnsemblParterial endothelial cell fate commitment
GO:0036302 ISS:BHF-UCLPatrioventricular canal development
GO:0009912 IEA:EnsemblPauditory receptor cell fate commitment
GO:0030183 IEA:EnsemblPB cell differentiation
GO:0097101 ISS:BHF-UCLPblood vessel endothelial cell fate specification
GO:0072554 ISS:BHF-UCLPblood vessel lumenization
GO:0001974 IEA:EnsemblPblood vessel remodeling
GO:0003214 ISS:BHF-UCLPcardiac left ventricle morphogenesis
GO:0060486 IEA:EnsemblPClara cell differentiation
GO:0042742 IEA:EnsemblPdefense response to bacterium
GO:0006310 NAS:UniProtKBPDNA recombination
GO:0035912 ISS:BHF-UCLPdorsal aorta morphogenesis
GO:0003160 ISS:BHF-UCLPendocardium morphogenesis
GO:0009957 IEA:EnsemblPepidermal cell fate specification
GO:0001837 ISS:BHF-UCLPepithelial to mesenchymal transition
GO:0003198 ISS:BHF-UCLPepithelial to mesenchymal transition involved in endocardial cushion formation
GO:0010467 TAS:ReactomePgene expression
GO:0048820 IEA:EnsemblPhair follicle maturation
GO:0006959 IEA:EnsemblPhumoral immune response
GO:0002437 IEA:EnsemblPinflammatory response to antigenic stimulus
GO:0072602 IEA:EnsemblPinterleukin-4 secretion
GO:0030216 IEA:EnsemblPkeratinocyte differentiation
GO:0060716 ISS:BHF-UCLPlabyrinthine layer blood vessel development
GO:0008285 IEA:EnsemblPnegative regulation of cell proliferation
GO:0030279 ISS:BHF-UCLPnegative regulation of ossification
GO:0045892 IDA:UniProtKBPnegative regulation of transcription, DNA-templated
GO:0000122 IMP:BHF-UCLPnegative regulation of transcription from RNA polymerase II promoter
GO:0061314 IC:BHF-UCLPNotch signaling involved in heart development
GO:0007219 IMP:BHF-UCLPNotch signaling pathway
GO:0003151 ISS:BHF-UCLPoutflow tract morphogenesis
GO:0021983 IEA:EnsemblPpituitary gland development
GO:0030513 ISS:BHF-UCLPpositive regulation of BMP signaling pathway
GO:1901297 IEA:EnsemblPpositive regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment
GO:0060045 ISS:BHF-UCLPpositive regulation of cardiac muscle cell proliferation
GO:2000138 ISS:BHF-UCLPpositive regulation of cell proliferation involved in heart morphogenesis
GO:1901189 ISS:BHF-UCLPpositive regulation of ephrin receptor signaling pathway
GO:1901186 ISS:BHF-UCLPpositive regulation of ERBB signaling pathway
GO:0045944 IMP:BHF-UCLPpositive regulation of transcription from RNA polymerase II promoter
GO:0007221 IDA:UniProtKBPpositive regulation of transcription of Notch receptor target
GO:0048505 IEA:EnsemblPregulation of timing of cell differentiation
GO:0003256 ISS:BHF-UCLPregulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation
GO:0048733 IEA:EnsemblPsebaceous gland development
GO:0003139 IEA:EnsemblPsecondary heart field specification
GO:0035019 IEA:EnsemblPsomatic stem cell maintenance
GO:0006367 TAS:ReactomePtranscription initiation from RNA polymerase II promoter
GO:0003222 ISS:BHF-UCLPventricular trabecula myocardium morphogenesis
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_160254Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
REACT_160243Constitutive Signaling by NOTCH1 PEST Domain Mutants
REACT_111045Developmental Biology
REACT_116125Disease
REACT_160099FBXW7 Mutants and NOTCH1 in Cancer
REACT_71Gene Expression
REACT_12627Generic Transcription Pathway
REACT_118780NOTCH1 Intracellular Domain Regulates Transcription
REACT_163910NOTCH2 intracellular domain regulates transcription
REACT_14835Notch-HLH transcription pathway
REACT_118744Pre-NOTCH Expression and Processing
REACT_118568Pre-NOTCH Transcription and Translation
REACT_13698Regulation of beta-cell development
REACT_13673Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells
REACT_299Signaling by NOTCH
REACT_118859Signaling by NOTCH1
REACT_160133Signaling by NOTCH1 HD Domain Mutants in Cancer
REACT_160248Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer
REACT_160214Signaling by NOTCH1 in Cancer
REACT_160301Signaling by NOTCH1 PEST Domain Mutants in Cancer
REACT_160082Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
REACT_118721Signaling by NOTCH2
REACT_111102Signal Transduction
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