MGP Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
MGP001602

UniProt Annotations

Entry Information
Gene Nameinterleukin 1 receptor, type I
Protein EntryIL1R1_HUMAN
UniProt IDP14778
SpeciesHuman
Comments
Comment typeDescription
FunctionReceptor for IL1A, IL1B and IL1RN. After binding to interleukin-1 associates with the corecptor IL1RAP to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B, MAPK and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Binds ligands with comparable affinity and binding of antagonist IL1RN prevents association with IL1RAP to form a signaling complex. {ECO:0000269|PubMed:10671496}.
InteractionQ9Y4K3:TRAF6; NbExp=2; IntAct=EBI-525905, EBI-359276;
PtmA soluble form (sIL1R1) is probably produced by proteolytic cleavage at the cell surface (shedding). {ECO:0000269|PubMed:8142597}.
PtmRapidly phosphorylated on Tyr-496 in response to IL-1, which creates a SH2 binding site for the PI 3-kinase regulatory subunit PIK3R1. {ECO:0000269|PubMed:9821957}.
SimilarityBelongs to the interleukin-1 receptor family. {ECO:0000305}.
SimilarityContains 1 TIR domain. {ECO:0000255|PROSITE- ProRule:PRU00204}.
SimilarityContains 3 Ig-like C2-type (immunoglobulin-like) domains. {ECO:0000305}.
Subcellular LocationMembrane {ECO:0000269|PubMed:8142597}; Single-pass type I membrane protein {ECO:0000269|PubMed:8142597}. Cell membrane {ECO:0000305|PubMed:8142597}. Secreted {ECO:0000269|PubMed:8142597}.
SubunitThe interleukin-1 receptor complex is a heterodimer of IL1R1 and IL1RAP. Interacts with PIK3R1. {ECO:0000269|PubMed:10903327, ECO:0000269|PubMed:9062193, ECO:0000269|PubMed:9062194, ECO:0000269|PubMed:9371760, ECO:0000269|PubMed:9821957}.
Web ResourceName=SeattleSNPs; URL="http://pga.gs.washington.edu/data/il1r1/";
  logo