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MGP001606

UniProt Annotations

Entry Information
Gene Nameinterleukin 2 receptor, beta
Protein EntryIL2RB_HUMAN
UniProt IDP14784
SpeciesHuman
Comments
Comment typeDescription
DomainThe box 1 motif is required for JAK interaction and/or activation.
DomainThe WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell- surface receptor binding.
FunctionReceptor for interleukin-2. This beta subunit is involved in receptor mediated endocytosis and transduces the mitogenic signals of IL2.
SimilarityBelongs to the type I cytokine receptor family. Type 4 subfamily. {ECO:0000305}.
SimilarityContains 1 fibronectin type-III domain. {ECO:0000255|PROSITE-ProRule:PRU00316}.
Subcellular LocationMembrane; Single-pass type I membrane protein.
SubunitNon-covalent dimer of an alpha and a beta subunit. IL2R exists in 3 different forms: a high affinity dimer, an intermediate affinity monomer (beta subunit), and a low affinity monomer (alpha subunit). The high and intermediate affinity forms also associate with a gamma subunit. Interacts with SHB upon interleukin stimulation. Interacts with HTLV-1 accessory protein p12I. {ECO:0000269|PubMed:12200137, ECO:0000269|PubMed:16293754, ECO:0000269|PubMed:16477002, ECO:0000269|PubMed:8648694}.
Web ResourceName=SeattleSNPs; URL="http://pga.gs.washington.edu/data/il2rb/";
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