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MGP001607

Record overview

MGPD IDMGP001607
Gene ID3561
SpeciesHomo sapiens (Human)
Gene Nameinterleukin 2 receptor, gamma
Gene Symbol IL2RG
SynonymsP64; CIDX; IMD4; CD132; SCIDX; IL-2RG; SCIDX1;
Alternate namescytokine receptor common subunit gamma; CD132 antigen; IL-2 receptor subunit gamma; IL-2R subunit gamma; common cytokine receptor gamma chain; gammaC;
ChromosomeX
Map LocationXq13.1
SummaryThe protein encoded by this gene is an important signaling component of many interleukin receptors, including those of interleukin -2, -4, -7 and -21, and is thus referred to as the common gamma chain. Mutations in this gene cause X-linked severe combined immunodeficiency (XSCID), as well as X-linked combined immunodeficiency (XCID), a less severe immunodeficiency disorder. [provided by RefSeq, Mar 2010]
OrthologsView orthologs and multiple alignments for IL2RG

Proteins

cytokine receptor common subunit gamma precursor
Refseq ID:NP_000197
Protein GI:4557882
UniProt ID:P31785
mRNA ID:NM_000206
Length:369
RefSeq Status:
MLKPSLPFTSLLFLQLPLLGVGLNTTILTPNGNEDTTADFFLTTMPTDSLSVSTLPLPEVQCFVFNVEYMNCTWNSSSEPQPTNLTLHYWYKNSDNDKVQ
KCSHYLFSEEITSGCQLQKKEIHLYQTFVVQLQDPREPRRQATQMLKLQNLVIPWAPENLTLHKLSESQLELNWNNRFLNHCLEHLVQYRTDWDHSWTEQ
SVDYRHKFSLPSVDGQKRYTFRVRSRFNPLCGSAQHWSEWSHPIHWGSNTSKENPFLFALEAVVISVGSMGLIISLLCVYFWLERTMPRIPTLKNLEDLV
TEYHGNFSAWSGVSKGLAESLQPDYSERLCLVSEIPPKGGALGEGPGASPCNQHSPYWAPPCYTLKPET
 
sig_peptide: 1..22
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2385
peptide sequence: 
MLKPSLPFTSLLFLQLPLLGVG

mat_peptide: 23..369
product: cytokine receptor common subunit gamma
calculated_mol_wt: 39920
peptide sequence: 
LNTTILTPNGNEDTTADFFLTTMPTDSLSVSTLPLPEVQCFVFNVEYMNCTWNSSSEPQPTNLTLHYWYKNSDNDKVQKCSHYLFSEEITSGCQLQKKEI
HLYQTFVVQLQDPREPRRQATQMLKLQNLVIPWAPENLTLHKLSESQLELNWNNRFLNHCLEHLVQYRTDWDHSWTEQSVDYRHKFSLPSVDGQKRYTFR
VRSRFNPLCGSAQHWSEWSHPIHWGSNTSKENPFLFALEAVVISVGSMGLIISLLCVYFWLERTMPRIPTLKNLEDLVTEYHGNFSAWSGVSKGLAESLQ
PDYSERLCLVSEIPPKGGALGEGPGASPCNQHSPYWAPPCYTLKPET
 
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