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MGP001609

UniProt Annotations

Entry Information
Gene Nameinterleukin 3 receptor, alpha (low affinity)
Protein EntryIL3RA_HUMAN
UniProt IDP26951
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; Synonyms=SP1; IsoId=P26951-1; Sequence=Displayed; Name=2; Synonyms=SP2; IsoId=P26951-2; Sequence=VSP_040622;
DomainThe box 1 motif is required for JAK interaction and/or activation.
DomainThe WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell- surface receptor binding.
FunctionThis is a receptor for interleukin-3.
MiscellaneousThe gene coding for this protein is located in the pseudoautosomal region 1 (PAR1) of X and Y chromosomes.
Sequence CautionSequence=BAA08393.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
SimilarityBelongs to the type I cytokine receptor family. Type 5 subfamily. {ECO:0000305}.
Subcellular LocationMembrane; Single-pass type I membrane protein.
SubunitHeterodimer of an alpha and a beta subunit. The beta subunit is common to the IL3, IL5 and GM-CSF receptors.
Web ResourceName=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/IL3RAID40959chXp22Yp13.html";
Web ResourceName=SeattleSNPs; URL="http://pga.gs.washington.edu/data/il3ra/";
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