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MGP001621

Record overview

MGPD IDMGP001621
Gene ID3596
SpeciesHomo sapiens (Human)
Gene Nameinterleukin 13
Gene Symbol IL13
SynonymsP600; IL-13;
Alternate namesinterleukin-13;
Chromosome5
Map Location5q31
SummaryThis gene encodes an immunoregulatory cytokine produced primarily by activated Th2 cells. This cytokine is involved in several stages of B-cell maturation and differentiation. It up-regulates CD23 and MHC class II expression, and promotes IgE isotype switching of B cells. This cytokine down-regulates macrophage activity, thereby inhibits the production of pro-inflammatory cytokines and chemokines. This cytokine is found to be critical to the pathogenesis of allergen-induced asthma but operates through mechanisms independent of IgE and eosinophils. This gene, IL3, IL5, IL4, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL4. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for IL13

Proteins

interleukin-13 precursor
Refseq ID:NP_002179
Protein GI:26787978
UniProt ID:P35225
mRNA ID:NM_002188
Length:146
RefSeq Status:
MHPLLNPLLLALGLMALLLTTVIALTCLGGFASPGPVPPSTALRELIEELVNITQNQKAPLCNGSMVWSINLTAGMYCAALESLINVSGCSAIEKTQRML
SGFCPHKVSAGQFSSLHVRDTKIEVAQFVKDLLLHLKKLFREGQFN
 
sig_peptide: 1..34
calculated_mol_wt: 3489
peptide sequence: 
MHPLLNPLLLALGLMALLLTTVIALTCLGGFASP

mat_peptide: 35..132
product: interleukin-13
calculated_mol_wt: 10591
peptide sequence: 
GPVPPSTALRELIEELVNITQNQKAPLCNGSMVWSINLTAGMYCAALESLINVSGCSAIEKTQRMLSGFCPHKVSAGQFSSLHVRDTKIEVAQFVKDL
 
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