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MGP001624

UniProt Annotations

Entry Information
Gene Nameinositol(myo)-1(or 4)-monophosphatase 1
Protein EntryIMPA1_HUMAN
UniProt IDP29218
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=3; Name=1; IsoId=P29218-1; Sequence=Displayed; Name=2; IsoId=P29218-2; Sequence=VSP_042521; Note=No experimental confirmation available.; Name=3; IsoId=P29218-3; Sequence=VSP_046308; Note=No experimental confirmation available. Ref.4 (BAH13340) sequence is in conflict in position: 17:Q->R. {ECO:0000305};
Biophysicochemical PropertiesKinetic parameters: KM=42 uM for D-myo-inositol 1-phosphate {ECO:0000269|PubMed:8068620}; KM=62 uM for L-myo-inositol 1-phosphate {ECO:0000269|PubMed:8068620}; pH dependence: Optimum pH is 7.0-7.5. {ECO:0000269|PubMed:17068342};
Catalytic ActivityAlpha-D-galactose 1-phosphate + H(2)O = D- galactose + phosphate. {ECO:0000269|PubMed:9462881}.
Catalytic ActivityMyo-inositol phosphate + H(2)O = myo-inositol + phosphate. {ECO:0000269|PubMed:1377913, ECO:0000269|PubMed:8068620, ECO:0000269|PubMed:8718889, ECO:0000269|PubMed:9462881}.
CofactorName=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000269|PubMed:17068342, ECO:0000269|PubMed:8718889, ECO:0000269|PubMed:9462881, ECO:0000303|PubMed:23027737, ECO:0000303|PubMed:8068621};
Enzyme RegulationActivity with myo-inositol monophosphate and D- galactose 1-phosphate is inhibited by Li(+), Ca(2+) and Mn(2+), but also by Mg(2+) at concentrations above 3 mM. {ECO:0000269|PubMed:17068342, ECO:0000269|PubMed:8718889, ECO:0000269|PubMed:9462881}.
FunctionResponsible for the provision of inositol required for synthesis of phosphatidylinositol and polyphosphoinositides and has been implicated as the pharmacological target for lithium action in brain. Has broad substrate specificity and can use myo- inositol monophosphates, myo-inositol 1,3-diphosphate, myo- inositol 1,4-diphosphate, scyllo-inositol-phosphate, D-galactose 1-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1- phosphate, beta-glycerophosphate, and 2'-AMP as substrates. {ECO:0000269|PubMed:17068342, ECO:0000269|PubMed:8718889, ECO:0000269|PubMed:9462881}.
InteractionSelf; NbExp=3; IntAct=EBI-752410, EBI-752410;
PathwayPolyol metabolism; myo-inositol biosynthesis; myo- inositol from D-glucose 6-phosphate: step 2/2.
SimilarityBelongs to the inositol monophosphatase family. {ECO:0000305}.
Subcellular LocationCytoplasm {ECO:0000269|PubMed:17068342}.
SubunitHomodimer. {ECO:0000269|PubMed:1332026, ECO:0000269|PubMed:23027737, ECO:0000269|PubMed:8068620, ECO:0000269|PubMed:8068621, ECO:0000269|PubMed:9462881}.
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