MGP Database

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MGP001625

UniProt Annotations

Entry Information
Gene Nameinositol(myo)-1(or 4)-monophosphatase 2
Protein EntryIMPA2_HUMAN
UniProt IDO14732
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=O14732-1; Sequence=Displayed; Name=2; Synonyms=A2b; IsoId=O14732-2; Sequence=VSP_013674;
Biophysicochemical PropertiesKinetic parameters: KM=5 mM for myo-inositol 1-monophosphate {ECO:0000269|PubMed:17068342}; pH dependence: Optimum pH is 7.5-8.0. {ECO:0000269|PubMed:17068342};
Catalytic ActivityMyo-inositol phosphate + H(2)O = myo-inositol + phosphate.
CofactorName=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000269|PubMed:17068342};
Enzyme RegulationInhibited by high Li(+) and restricted Mg(2+) concentrations. {ECO:0000269|PubMed:15504365, ECO:0000269|PubMed:17068342}.
FunctionCan use myo-inositol monophosphates, scylloinositol 1,4- diphosphate, glucose-1-phosphate, beta-glycerophosphate, and 2'- AMP as substrates. Has been implicated as the pharmacological target for lithium Li(+) action in brain. {ECO:0000269|PubMed:17068342}.
InductionRepressed by Li(+).
PathwayPolyol metabolism; myo-inositol biosynthesis; myo- inositol from D-glucose 6-phosphate: step 2/2.
SimilarityBelongs to the inositol monophosphatase family. {ECO:0000305}.
SubunitHomodimer. {ECO:0000269|PubMed:17340635}.
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