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MGP001629

UniProt Annotations

Entry Information
Gene Nameinhibin, beta A
Protein EntryINHBA_HUMAN
UniProt IDP08476
SpeciesHuman
Comments
Comment typeDescription
FunctionInhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.
InteractionP21674:Fst (xeno); NbExp=2; IntAct=EBI-8077140, EBI-5746973;
SimilarityBelongs to the TGF-beta family. {ECO:0000305}.
Subcellular LocationSecreted.
SubunitDimeric, linked by one or more disulfide bonds. Inhibin A is a dimer of alpha and beta-A. Inhibin B is a dimer of alpha and beta-B. Activin A is a homodimer of beta-A. Activin B is a homodimer of beta-B. Activin AB is a dimer of beta-A and beta-B. Interacts with FST and FSTL3. {ECO:0000269|PubMed:12660162, ECO:0000269|PubMed:12697670, ECO:0000269|PubMed:18768470}.
Web ResourceName=Wikipedia; Note=Activin entry; URL="http://en.wikipedia.org/wiki/Activin";
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