MGP Database

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MGP001635

UniProt Annotations

Entry Information
Gene Nameinositol polyphosphate-4-phosphatase, type I, 107kDa
Protein EntryINP4A_HUMAN
UniProt IDQ96PE3
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=4; Name=1; Synonyms=Alpha-3; IsoId=Q96PE3-1; Sequence=Displayed; Name=2; Synonyms=Alpha-1; IsoId=Q96PE3-2; Sequence=VSP_015241; Name=3; IsoId=Q96PE3-3; Sequence=VSP_015240; Name=4; Synonyms=Beta; IsoId=Q96PE3-4; Sequence=VSP_015241, VSP_015242; Note=Inactive.;
Catalytic Activity1-phosphatidyl-myo-inositol 3,4-bisphosphate + H(2)O = 1-phosphatidyl-1D-myo-inositol 3-phosphate + phosphate.
FunctionCatalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 3,4-bisphosphate, inositol 1,3,4- trisphosphate and inositol 3,4-bisphosphate.
PathwaySignal transduction; phosphatidylinositol signaling pathway.
SimilarityBelongs to the inositol 3,4-bisphosphate 4-phosphatase family. {ECO:0000305}.
SimilarityContains 1 C2 domain. {ECO:0000305}.
Tissue SpecificityIsoform 1 is expressed in the platelets, MEG- 01 megakaryocytes and Jurkat T-cells. Isoform 2 is expressed in the brain. {ECO:0000269|PubMed:11485317}.
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