MGP Database

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MGP001643

Ontology/Pathway Information

Entrez Gene ID3643
Gene Nameinsulin receptor
Gene Symbol INSR
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005901 IDA:BHF-UCLCcaveola
GO:0010008 TAS:ReactomeCendosome membrane
GO:0070062 IDA:UniProtKBCextracellular vesicular exosome
GO:0005899 IMP:BHF-UCLCinsulin receptor complex
GO:0005887 IDA:BHF-UCLCintegral component of plasma membrane
GO:0043231 IDA:HPACintracellular membrane-bounded organelle
GO:0016020 IDA:BHF-UCLCmembrane
GO:0005886 IC:BHF-UCLCplasma membrane
GO:0043235 IDA:MGICreceptor complex
GO:0005524 IDA:BHF-UCLFATP binding
GO:0005525 IDA:BHF-UCLFGTP binding
GO:0005009 IDA:UniProtKBFinsulin-activated receptor activity
GO:0043559 IDA:UniProtKBFinsulin binding
GO:0031994 IPI:BHF-UCLFinsulin-like growth factor I binding
GO:0031995 IPI:BHF-UCLFinsulin-like growth factor II binding
GO:0005159 IDA:BHF-UCLFinsulin-like growth factor receptor binding
GO:0043560 IPI:UniProtKBFinsulin receptor substrate binding
GO:0043548 IPI:UniProtKBFphosphatidylinositol 3-kinase binding
GO:0004713 IMP:UniProtKBFprotein tyrosine kinase activity
GO:0051425 IPI:UniProtKBFPTB domain binding
GO:0004716 IDA:BHF-UCLFreceptor signaling protein tyrosine kinase activity
GO:0000187 IMP:BHF-UCLPactivation of MAPK activity
GO:0032147 IMP:BHF-UCLPactivation of protein kinase activity
GO:0032148 IDA:BHF-UCLPactivation of protein kinase B activity
GO:0005975 IEA:UniProtKB-KWPcarbohydrate metabolic process
GO:0071363 IEA:EnsemblPcellular response to growth factor stimulus
GO:0032869 IDA:BHF-UCLPcellular response to insulin stimulus
GO:0008544 IEA:EnsemblPepidermis development
GO:0031017 IEA:EnsemblPexocrine pancreas development
GO:0042593 IMP:BHF-UCLPglucose homeostasis
GO:0007186 IDA:BHF-UCLPG-protein coupled receptor signaling pathway
GO:0003007 IMP:BHF-UCLPheart morphogenesis
GO:0008286 IDA:UniProtKBPinsulin receptor signaling pathway
GO:0030238 IEA:EnsemblPmale sex determination
GO:0038083 IEA:EnsemblPpeptidyl-tyrosine autophosphorylation
GO:0018108 IDA:BHF-UCLPpeptidyl-tyrosine phosphorylation
GO:0030335 IMP:BHF-UCLPpositive regulation of cell migration
GO:0008284 IDA:BHF-UCLPpositive regulation of cell proliferation
GO:0048639 IMP:BHF-UCLPpositive regulation of developmental growth
GO:0045740 IMP:BHF-UCLPpositive regulation of DNA replication
GO:0046326 IDA:BHF-UCLPpositive regulation of glucose import
GO:0045725 IDA:BHF-UCLPpositive regulation of glycogen biosynthetic process
GO:0045821 IMP:BHF-UCLPpositive regulation of glycolytic process
GO:0043410 IMP:BHF-UCLPpositive regulation of MAPK cascade
GO:0045840 IMP:BHF-UCLPpositive regulation of mitosis
GO:0045429 IMP:BHF-UCLPpositive regulation of nitric oxide biosynthetic process
GO:0051897 IMP:BHF-UCLPpositive regulation of protein kinase B signaling
GO:0001934 IDA:BHF-UCLPpositive regulation of protein phosphorylation
GO:0060267 IDA:BHF-UCLPpositive regulation of respiratory burst
GO:0046777 IMP:UniProtKBPprotein autophosphorylation
GO:0051290 IDA:UniProtKBPprotein heterotetramerization
GO:0045995 IMP:BHF-UCLPregulation of embryonic development
GO:0006355 IMP:BHF-UCLPregulation of transcription, DNA-templated
GO:0023014 IDA:GOCPsignal transduction by phosphorylation
GO:0019087 IMP:BHF-UCLPtransformation of host cell by virus
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_1109Insulin receptor recycling
REACT_1195Insulin receptor signalling cascade
REACT_570IRS activation
REACT_762IRS-related events
REACT_1661SHC activation
REACT_999SHC-related events
REACT_508Signal attenuation
REACT_498Signaling by Insulin receptor
REACT_111102Signal Transduction
SMP Pathway Links
SMP IDDescription
SMP00391Insulin Signalling
SMP00682Leucine Stimulation on Insulin Signaling
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