MGP Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
MGP001646

Ontology/Pathway Information

Entrez Gene ID3654
Gene Nameinterleukin-1 receptor-associated kinase 1
Gene Symbol IRAK1
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005737 IDA:HPACcytoplasm
GO:0005829 TAS:ReactomeCcytosol
GO:0010008 TAS:ReactomeCendosome membrane
GO:0045323 NAS:UniProtKBCinterleukin-1 receptor complex
GO:0005811 ISS:UniProtKBClipid particle
GO:0005634 IDA:HPACnucleus
GO:0005886 TAS:ReactomeCplasma membrane
GO:0005524 IEA:UniProtKB-KWFATP binding
GO:0016301 IDA:MGIFkinase activity
GO:0004704 TAS:ProtIncFNF-kappaB-inducing kinase activity
GO:0046982 IPI:BHF-UCLFprotein heterodimerization activity
GO:0042803 NAS:UniProtKBFprotein homodimerization activity
GO:0004672 IDA:MGIFprotein kinase activity
GO:0004674 NAS:UniProtKBFprotein serine/threonine kinase activity
GO:0004842 TAS:ReactomeFubiquitin-protein transferase activity
GO:0000187 TAS:ReactomePactivation of MAPK activity
GO:0007250 IDA:UniProtKBPactivation of NF-kappaB-inducing kinase activity
GO:0007568 IEA:EnsemblPaging
GO:0034605 IEA:EnsemblPcellular response to heat
GO:0071456 IEA:EnsemblPcellular response to hypoxia
GO:0045087 TAS:ReactomePinnate immune response
GO:0070498 IMP:BHF-UCLPinterleukin-1-mediated signaling pathway
GO:0007254 TAS:ReactomePJNK cascade
GO:0031663 IMP:BHF-UCLPlipopolysaccharide-mediated signaling pathway
GO:0002755 TAS:BHF-UCLPMyD88-dependent toll-like receptor signaling pathway
GO:0002756 TAS:ReactomePMyD88-independent toll-like receptor signaling pathway
GO:0043066 TAS:ReactomePnegative regulation of apoptotic process
GO:0032088 IMP:BHF-UCLPnegative regulation of NF-kappaB transcription factor activity
GO:0048011 TAS:ReactomePneurotrophin TRK receptor signaling pathway
GO:0035872 TAS:ReactomePnucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
GO:0070423 TAS:ReactomePnucleotide-binding oligomerization domain containing signaling pathway
GO:0043123 IMP:MGIPpositive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043406 IBA:GO_CentralPpositive regulation of MAP kinase activity
GO:0051092 IDA:BHF-UCLPpositive regulation of NF-kappaB transcription factor activity
GO:0048661 IEA:EnsemblPpositive regulation of smooth muscle cell proliferation
GO:0045893 NAS:UniProtKBPpositive regulation of transcription, DNA-templated
GO:0046777 NAS:UniProtKBPprotein autophosphorylation
GO:0051259 IMP:UniProtKBPprotein oligomerization
GO:0006468 TAS:ProtIncPprotein phosphorylation
GO:0016567 TAS:GOCPprotein ubiquitination
GO:0001959 IMP:BHF-UCLPregulation of cytokine-mediated signaling pathway
GO:0070555 IMP:BHF-UCLPresponse to interleukin-1
GO:0032496 IMP:BHF-UCLPresponse to lipopolysaccharide
GO:0032494 IEA:EnsemblPresponse to peptidoglycan
GO:0007165 NAS:UniProtKBPsignal transduction
GO:0051403 TAS:ReactomePstress-activated MAPK cascade
GO:0034166 TAS:ReactomePtoll-like receptor 10 signaling pathway
GO:0034134 IMP:BHF-UCLPtoll-like receptor 2 signaling pathway
GO:0034138 TAS:ReactomePtoll-like receptor 3 signaling pathway
GO:0034142 IBA:GO_CentralPtoll-like receptor 4 signaling pathway
GO:0034146 TAS:ReactomePtoll-like receptor 5 signaling pathway
GO:0034162 TAS:ReactomePtoll-like receptor 9 signaling pathway
GO:0002224 TAS:ReactomePtoll-like receptor signaling pathway
GO:0038123 TAS:ReactomePtoll-like receptor TLR1:TLR2 signaling pathway
GO:0038124 TAS:ReactomePtoll-like receptor TLR6:TLR2 signaling pathway
GO:0007178 NAS:UniProtKBPtransmembrane receptor protein serine/threonine kinase signaling pathway
GO:0035666 TAS:ReactomePTRIF-dependent toll-like receptor signaling pathway
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_21399activated TAK1 mediates p38 MAPK activation
REACT_6890Activated TLR4 signalling
REACT_75790Cytokine Signaling in Immune system
REACT_6900Immune System
REACT_6802Innate Immune System
REACT_22442Interleukin-1 signaling
REACT_24918IRAK1 recruits IKK complex
REACT_25354IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
REACT_21368JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
REACT_21308MAP kinase activation in TLR cascade
REACT_27215MyD88 cascade initiated on plasma membrane
REACT_25222MyD88 dependent cascade initiated on endosome
REACT_6809MyD88-independent cascade
REACT_6788MyD88:Mal cascade initiated on plasma membrane
REACT_13696NF-kB is activated and signals survival
REACT_75776NOD1/2 Signaling Pathway
REACT_75913Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
REACT_13776p75 NTR receptor-mediated signalling
REACT_13415p75NTR recruits signalling complexes
REACT_13537p75NTR signals via NF-kB
REACT_22232Signaling by Interleukins
REACT_11061Signalling by NGF
REACT_111102Signal Transduction
REACT_21281TAK1 activates NFkB by phosphorylation and activation of IKKs complex
REACT_9027Toll Like Receptor 10 (TLR10) Cascade
REACT_7980Toll Like Receptor 2 (TLR2) Cascade
REACT_6783Toll Like Receptor 3 (TLR3) Cascade
REACT_6894Toll Like Receptor 4 (TLR4) Cascade
REACT_9061Toll Like Receptor 5 (TLR5) Cascade
REACT_9020Toll Like Receptor 7/8 (TLR7/8) Cascade
REACT_9047Toll Like Receptor 9 (TLR9) Cascade
REACT_6966Toll-Like Receptors Cascades
REACT_8005Toll Like Receptor TLR1:TLR2 Cascade
REACT_8006Toll Like Receptor TLR6:TLR2 Cascade
REACT_25024TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
REACT_25120TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
REACT_25281TRIF-mediated TLR3/TLR4 signaling
  logo