MGP Database

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MGP001655

Ontology/Pathway Information

Entrez Gene ID3665
Gene Nameinterferon regulatory factor 7
Gene Symbol IRF7
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005737 TAS:ProtIncCcytoplasm
GO:0005829 TAS:ReactomeCcytosol
GO:0010008 TAS:ReactomeCendosome membrane
GO:0005654 TAS:ReactomeCnucleoplasm
GO:0005634 TAS:ProtIncCnucleus
GO:0003677 IMP:UniProtKBFDNA binding
GO:0000982 IDA:UniProtKBFRNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity
GO:0000979 IDA:UniProtKBFRNA polymerase II core promoter sequence-specific DNA binding
GO:0006974 TAS:UniProtKBPcellular response to DNA damage stimulus
GO:0019221 TAS:ReactomePcytokine-mediated signaling pathway
GO:0019043 TAS:UniProtKBPestablishment of viral latency
GO:0016064 IEA:EnsemblPimmunoglobulin mediated immune response
GO:0045087 TAS:UniProtKBPinnate immune response
GO:0032607 ISS:UniProtKBPinterferon-alpha production
GO:0032608 ISS:UniProtKBPinterferon-beta production
GO:0060333 TAS:ReactomePinterferon-gamma-mediated signaling pathway
GO:0039530 TAS:UniProtKBPMDA-5 signaling pathway
GO:0002756 TAS:ReactomePMyD88-independent toll-like receptor signaling pathway
GO:2000110 TAS:UniProtKBPnegative regulation of macrophage apoptotic process
GO:0000122 TAS:ProtIncPnegative regulation of transcription from RNA polymerase II promoter
GO:0032727 TAS:UniProtKBPpositive regulation of interferon-alpha production
GO:0032728 TAS:UniProtKBPpositive regulation of interferon-beta production
GO:0045893 IMP:UniProtKBPpositive regulation of transcription, DNA-templated
GO:0045944 IDA:UniProtKBPpositive regulation of transcription from RNA polymerase II promoter
GO:0060340 IEA:EnsemblPpositive regulation of type I interferon-mediated signaling pathway
GO:0032481 TAS:ReactomePpositive regulation of type I interferon production
GO:0002819 IDA:UniProtKBPregulation of adaptive immune response
GO:0050776 TAS:UniProtKBPregulation of immune response
GO:0045655 TAS:UniProtKBPregulation of monocyte differentiation
GO:0034124 ISS:UniProtKBPregulation of MyD88-dependent toll-like receptor signaling pathway
GO:0034127 ISS:UniProtKBPregulation of MyD88-independent toll-like receptor signaling pathway
GO:0032479 TAS:UniProtKBPregulation of type I interferon production
GO:0009615 TAS:UniProtKBPresponse to virus
GO:0034138 TAS:ReactomePtoll-like receptor 3 signaling pathway
GO:0034142 TAS:ReactomePtoll-like receptor 4 signaling pathway
GO:0034162 TAS:ReactomePtoll-like receptor 9 signaling pathway
GO:0002224 TAS:ReactomePtoll-like receptor signaling pathway
GO:0006366 TAS:ProtIncPtranscription from RNA polymerase II promoter
GO:0035666 TAS:ReactomePTRIF-dependent toll-like receptor signaling pathway
GO:0045351 IEA:EnsemblPtype I interferon biosynthetic process
GO:0060337 TAS:ReactomePtype I interferon signaling pathway
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_6890Activated TLR4 signalling
REACT_25148Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
REACT_75790Cytokine Signaling in Immune system
REACT_118823Cytosolic sensors of pathogen-associated DNA
REACT_163773DEx/H-box helicases activate type I IFN and inflammatory cytokines production
REACT_24970Factors involved in megakaryocyte development and platelet production
REACT_604Hemostasis
REACT_6900Immune System
REACT_6802Innate Immune System
REACT_25162Interferon alpha/beta signaling
REACT_25078Interferon gamma signaling
REACT_25229Interferon Signaling
REACT_25222MyD88 dependent cascade initiated on endosome
REACT_6809MyD88-independent cascade
REACT_25359RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
REACT_6783Toll Like Receptor 3 (TLR3) Cascade
REACT_6894Toll Like Receptor 4 (TLR4) Cascade
REACT_9020Toll Like Receptor 7/8 (TLR7/8) Cascade
REACT_9047Toll Like Receptor 9 (TLR9) Cascade
REACT_6966Toll-Like Receptors Cascades
REACT_25026TRAF3-dependent IRF activation pathway
REACT_24938TRAF6 mediated IRF7 activation
REACT_25120TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
REACT_25281TRIF-mediated TLR3/TLR4 signaling
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