MGP Database

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MGP001656

Ontology/Pathway Information

Entrez Gene ID3667
Gene Nameinsulin receptor substrate 1
Gene Symbol IRS1
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005901 IDA:BHF-UCLCcaveola
GO:0036064 IEA:EnsemblCciliary basal body
GO:0005737 ISS:UniProtKBCcytoplasm
GO:0005829 IBA:GO_CentralCcytosol
GO:0005899 ISS:BHF-UCLCinsulin receptor complex
GO:0043231 ISS:UniProtKBCintracellular membrane-bounded organelle
GO:0005634 ISS:UniProtKBCnucleus
GO:0005886 TAS:ReactomeCplasma membrane
GO:0005159 IPI:UniProtKBFinsulin-like growth factor receptor binding
GO:0005158 IPI:UniProtKBFinsulin receptor binding
GO:0043548 IPI:UniProtKBFphosphatidylinositol 3-kinase binding
GO:0005080 ISS:BHF-UCLFprotein kinase C binding
GO:0042169 ISS:UniProtKBFSH2 domain binding
GO:0004871 TAS:ProtIncFsignal transducer activity
GO:0005068 ISS:BHF-UCLFtransmembrane receptor protein tyrosine kinase adaptor activity
GO:0032869 IMP:BHF-UCLPcellular response to insulin stimulus
GO:0007173 TAS:ReactomePepidermal growth factor receptor signaling pathway
GO:0038095 TAS:ReactomePFc-epsilon receptor signaling pathway
GO:0008543 TAS:ReactomePfibroblast growth factor receptor signaling pathway
GO:0042593 TAS:BHF-UCLPglucose homeostasis
GO:0045087 TAS:ReactomePinnate immune response
GO:0048009 IPI:UniProtKBPinsulin-like growth factor receptor signaling pathway
GO:0008286 IPI:UniProtKBPinsulin receptor signaling pathway
GO:0060397 TAS:ReactomePJAK-STAT cascade involved in growth hormone signaling pathway
GO:0016042 IEA:EnsemblPlipid catabolic process
GO:0030879 IEA:EnsemblPmammary gland development
GO:0046627 ISS:BHF-UCLPnegative regulation of insulin receptor signaling pathway
GO:0046676 IDA:BHF-UCLPnegative regulation of insulin secretion
GO:0048011 TAS:ReactomePneurotrophin TRK receptor signaling pathway
GO:0014065 IDA:BHF-UCLPphosphatidylinositol 3-kinase signaling
GO:0048015 TAS:ReactomePphosphatidylinositol-mediated signaling
GO:0030335 IEA:EnsemblPpositive regulation of cell migration
GO:0008284 NAS:BHF-UCLPpositive regulation of cell proliferation
GO:0032000 IMP:BHF-UCLPpositive regulation of fatty acid beta-oxidation
GO:0046326 IMP:BHF-UCLPpositive regulation of glucose import
GO:2001275 IDA:BHF-UCLPpositive regulation of glucose import in response to insulin stimulus
GO:0010907 IMP:BHF-UCLPpositive regulation of glucose metabolic process
GO:0045725 IMP:BHF-UCLPpositive regulation of glycogen biosynthetic process
GO:0046628 ISS:BHF-UCLPpositive regulation of insulin receptor signaling pathway
GO:0002053 IEA:EnsemblPpositive regulation of mesenchymal cell proliferation
GO:0043552 ISS:BHF-UCLPpositive regulation of phosphatidylinositol 3-kinase activity
GO:0043491 IEA:EnsemblPprotein kinase B signaling
GO:0034504 IEA:EnsemblPprotein localization to nucleus
GO:0010468 IEA:EnsemblPregulation of gene expression
GO:0032868 IDA:BHF-UCLPresponse to insulin
GO:0043434 ISS:BHF-UCLPresponse to peptide hormone
GO:0007165 TAS:ProtIncPsignal transduction
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_75774Adaptive Immune System
REACT_147727Constitutive PI3K/AKT Signaling in Cancer
REACT_75790Cytokine Signaling in Immune system
REACT_147694DAP12 interactions
REACT_147814DAP12 signaling
REACT_116125Disease
REACT_118638Downstream signaling events of B Cell Receptor (BCR)
REACT_21272Downstream signaling of activated FGFR
REACT_17025Downstream signal transduction
REACT_163936Fc epsilon receptor (FCERI) signaling
REACT_12578GAB1 signalosome
REACT_111133Growth hormone receptor signaling
REACT_150210IGF1R signaling cascade
REACT_6900Immune System
REACT_6802Innate Immune System
REACT_1195Insulin receptor signalling cascade
REACT_570IRS activation
REACT_332IRS-mediated signalling
REACT_762IRS-related events
REACT_150203IRS-related events triggered by IGF1R
REACT_12056NGF signalling via TRKA from the plasma membrane
REACT_12464PI3K/AKT activation
REACT_147723PI3K/AKT Signaling in Cancer
REACT_21270PI-3K cascade
REACT_976PI3K Cascade
REACT_116008PI3K events in ERBB2 signaling
REACT_115961PI3K events in ERBB4 signaling
REACT_75829PIP3 activates AKT signaling
REACT_163769Role of LAT2/NTAL/LAB on calcium mobilization
REACT_508Signal attenuation
REACT_9417Signaling by EGFR
REACT_115871Signaling by EGFR in Cancer
REACT_268269Signaling by EGFRvIII in Cancer
REACT_115755Signaling by ERBB2
REACT_115596Signaling by ERBB4
REACT_9470Signaling by FGFR
REACT_120736Signaling by FGFR in disease
REACT_498Signaling by Insulin receptor
REACT_169118Signaling by Leptin
REACT_268006Signaling by Ligand-Responsive EGFR Variants in Cancer
REACT_268546Signaling by Overexpressed Wild-Type EGFR in Cancer
REACT_16888Signaling by PDGF
REACT_111040Signaling by SCF-KIT
REACT_118773Signaling by the B Cell Receptor (BCR)
REACT_150359Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
REACT_11061Signalling by NGF
REACT_111102Signal Transduction
REACT_524SOS-mediated signalling
SMP Pathway Links
SMP IDDescription
SMP00391Insulin Signalling
SMP00682Leucine Stimulation on Insulin Signaling
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