MGP Database

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MGP001657

UniProt Annotations

Entry Information
Gene Nameinterferon stimulated exonuclease gene 20kDa
Protein Entry
UniProt ID
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q96AZ6-1; Sequence=Displayed; Name=2; IsoId=Q96AZ6-2; Sequence=VSP_012429, VSP_012430; Note=No experimental confirmation available.;
Biophysicochemical PropertiespH dependence: Optimum pH is 7.0.;
Catalytic ActivityExonucleolytic cleavage in the 3'- to 5'- direction to yield nucleoside 5'-phosphates.
CofactorName=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000269|PubMed:15527770}; Note=Binds 2 manganese ions per subunit. {ECO:0000269|PubMed:15527770};
FunctionInterferon-induced antiviral exoribonuclease that acts on single-stranded RNA and also has minor activity towards single- stranded DNA. Exhibits antiviral activity against RNA viruses including hepatitis C virus (HCV), hepatitis A virus (HAV) and yellow fever virus (YFV) in an exonuclease-dependent manner. May also play additional roles in the maturation of snRNAs and rRNAs, and in ribosome biogenesis. {ECO:0000269|PubMed:11401564, ECO:0000269|PubMed:12594219, ECO:0000269|PubMed:16033969, ECO:0000269|PubMed:21036379}.
InductionInduced by interferons alpha and beta. Weaker induction was seen with interferon gamma. Increased expression was seen at the transcriptional level. {ECO:0000269|PubMed:9235947}.
SimilarityBelongs to the exonuclease superfamily. {ECO:0000305}.
Subcellular LocationNucleus. Nucleus, nucleolus. Cytoplasm. Nucleus, Cajal body.
SubunitAssociates with PML and SP100 in the PML NB complex. Associates with survival motor neuron protein (SMN)-containing macromolecular nuclear complexes and U1 and U2 snRNAs and U3 snoRNA. {ECO:0000269|PubMed:15527770, ECO:0000269|PubMed:9235947}.
Tissue SpecificityHighly expressed in peripheral blood leukocytes, spleen, thymus, colon and lung. Up regulated by E2 in estrogen receptor-positive breast cancer lines. {ECO:0000269|PubMed:9235947, ECO:0000269|PubMed:9569007}.
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