MGP Database

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MGP001668

UniProt Annotations

Entry Information
Gene Nameintegrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide)
Protein EntryITAE_HUMAN
UniProt IDP38570
SpeciesHuman
Comments
Comment typeDescription
DomainThe integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.
FunctionIntegrin alpha-E/beta-7 is a receptor for E-cadherin. It mediates adhesion of intra-epithelial T-lymphocytes to epithelial cell monolayers.
InductionIntegrin alpha-E/beta-7 is induced by TGFB1. {ECO:0000269|PubMed:1542691}.
SimilarityBelongs to the integrin alpha chain family. {ECO:0000305}.
SimilarityContains 1 VWFA domain. {ECO:0000255|PROSITE- ProRule:PRU00219}.
SimilarityContains 7 FG-GAP repeats. {ECO:0000305}.
Subcellular LocationMembrane; Single-pass type I membrane protein.
SubunitHeterodimer of an alpha and a beta subunit. The alpha subunit is composed of a heavy and a light chains linked by a disulfide bond. Alpha-E associates with beta-7.
Tissue SpecificityExpressed on a subclass of T-lymphocytes known as intra-epithelial lymphocytes which are located between mucosal epithelial cells.
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