MGP Database

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MGP001672

UniProt Annotations

Entry Information
Gene Nameintegrin, alpha X (complement component 3 receptor 4 subunit)
Protein EntryITAX_HUMAN
UniProt IDP20702
SpeciesHuman
Comments
Comment typeDescription
DomainThe integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.
FunctionIntegrin alpha-X/beta-2 is a receptor for fibrinogen. It recognizes the sequence G-P-R in fibrinogen. It mediates cell-cell interaction during inflammatory responses. It is especially important in monocyte adhesion and chemotaxis.
SimilarityBelongs to the integrin alpha chain family. {ECO:0000305}.
SimilarityContains 1 VWFA domain. {ECO:0000255|PROSITE- ProRule:PRU00219}.
SimilarityContains 7 FG-GAP repeats. {ECO:0000305}.
Subcellular LocationMembrane; Single-pass type I membrane protein.
SubunitHeterodimer of an alpha and a beta subunit. Alpha-X associates with beta-2. {ECO:0000269|PubMed:20033057}.
Tissue SpecificityPredominantly expressed in monocytes and granulocytes.
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