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MGP001677

UniProt Annotations

Entry Information
Gene Nameintegrin, beta 6
Protein Entry
UniProt ID
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=P18564-1; Sequence=Displayed; Name=2; IsoId=P18564-2; Sequence=VSP_055189; Note=No experimental confirmation available. Gene prediction confirmed by EST data.;
FunctionIntegrin alpha-V/beta-6 is a receptor for fibronectin and cytotactin. It recognizes the sequence R-G-D in its ligands. Internalisation of integrin alpha-V/beta-6 via clathrin-mediated endocytosis promotes carcinoma cell invasion. {ECO:0000269|PubMed:17545607}.
SimilarityBelongs to the integrin beta chain family. {ECO:0000305}.
SimilarityContains 1 VWFA domain. {ECO:0000305}.
Subcellular LocationMembrane; Single-pass type I membrane protein.
SubunitHeterodimer of an alpha and a beta subunit. Beta-6 associates with alpha-V. Interacts with FLNB. Interacts with HAX1. Alpha-V/beta-6 binds to foot-and-mouth disease virus (FMDV) VP1 protein, coxsackievirus A9, coxsackievirus B1 capsid proteins and acts as a receptor for these viruses. {ECO:0000269|PubMed:10799568, ECO:0000269|PubMed:11807098, ECO:0000269|PubMed:15194773, ECO:0000269|PubMed:16973584, ECO:0000269|PubMed:17545607, ECO:0000269|PubMed:9426447}.
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