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MGP001684

Record overview

MGPD IDMGP001684
Gene ID3706
SpeciesHomo sapiens (Human)
Gene Nameinositol-trisphosphate 3-kinase A
Gene Symbol ITPKA
SynonymsIP3KA; IP3-3KA;
Alternate namesinositol-trisphosphate 3-kinase A; IP3 3-kinase A; IP3K A; inositol 1,4,5-trisphosphate 3-kinase A; insP 3-kinase A;
Chromosome15
Map Location15q15.1
EC Number2.7.1.127
SummaryRegulates inositol phosphate metabolism by phosphorylation of second messenger inositol 1,4,5-trisphosphate to Ins(1,3,4,5)P4. The activity of the inositol 1,4,5-trisphosphate 3-kinase is responsible for regulating the levels of a large number of inositol polyphosphates that are important in cellular signaling. Both calcium/calmodulin and protein phosphorylation mechanisms control its activity. It is also a substrate for the cyclic AMP-dependent protein kinase, calcium/calmodulin- dependent protein kinase II, and protein kinase C in vitro.[provided by RefSeq, Apr 2011]
OrthologsView orthologs and multiple alignments for ITPKA

Proteins

inositol-trisphosphate 3-kinase A
Refseq ID:NP_002211
Protein GI:4504789
UniProt ID:P23677
mRNA ID:NM_002220
Length:461
RefSeq Status:
MTLPGGPTGMARPGGARPCSPGLERAPRRSVGELRLLFEARCAAVAAAAAAGEPRARGAKRRGGQVPNGLPRAPPAPVIPQLTVTAEEPDVPPTSPGPPE
RERDCLPAAGSSHLQQPRRLSTSSVSSTGSSSLLEDSEDDLLSDSESRSRGNVQLEAGEDVGQKNHWQKIRTMVNLPVISPFKKRYAWVQLAGHTGSFKA
AGTSGLILKRCSEPERYCLARLMADALRGCVPAFHGVVERDGESYLQLQDLLDGFDGPCVLDCKMGVRTYLEEELTKARERPKLRKDMYKKMLAVDPEAP
TEEEHAQRAVTKPRYMQWREGISSSTTLGFRIEGIKKADGSCSTDFKTTRSREQVLRVFEEFVQGDEEVLRRYLNRLQQIRDTLEVSEFFRRHEVIGSSL
LFVHDHCHRAGVWLIDFGKTTPLPDGQILDHRRPWEEGNREDGYLLGLDNLIGILASLAER
 
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