MGP Database

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MGP001685

UniProt Annotations

Entry Information
Gene Nameinositol-trisphosphate 3-kinase B
Protein EntryIP3KB_HUMAN
UniProt IDP27987
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=P27987-1; Sequence=Displayed; Name=2; IsoId=P27987-2; Sequence=VSP_016092; Note=No experimental confirmation available.;
Catalytic ActivityATP + 1D-myo-inositol 1,4,5-trisphosphate = ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate.
Enzyme RegulationIP3K is activated by calmodulin. Form B is much more sensitive to calcium/calmodulin than form A.
Sequence CautionSequence=CAA40491.1; Type=Erroneous initiation; Evidence={ECO:0000305};
SimilarityBelongs to the inositol phosphokinase (IPK) family. {ECO:0000305}.
SubunitInteracts with DMTN. {ECO:0000269|PubMed:23060452}.
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