MGP Database

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MGP001686

Ontology/Pathway Information

Entrez Gene ID3708
Gene Nameinositol 1,4,5-trisphosphate receptor, type 1
Gene Symbol ITPR1
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005955 IEA:EnsemblCcalcineurin complex
GO:0005783 NAS:UniProtKBCendoplasmic reticulum
GO:0005789 TAS:ReactomeCendoplasmic reticulum membrane
GO:0016021 IEA:UniProtKB-KWCintegral component of membrane
GO:0016020 IDA:UniProtKBCmembrane
GO:0005637 IEA:EnsemblCnuclear inner membrane
GO:0005730 IEA:EnsemblCnucleolus
GO:0031088 IDA:BHF-UCLCplatelet dense granule membrane
GO:0031094 IDA:BHF-UCLCplatelet dense tubular network
GO:0031095 TAS:ReactomeCplatelet dense tubular network membrane
GO:0014069 IEA:EnsemblCpostsynaptic density
GO:0016529 IEA:EnsemblCsarcoplasmic reticulum
GO:0019855 IDA:GO_CentralFcalcium channel inhibitor activity
GO:0015085 TAS:ProtIncFcalcium ion transmembrane transporter activity
GO:0005220 ISS:UniProtKBFinositol 1,4,5-trisphosphate-sensitive calcium-release channel activity
GO:0005218 ISS:UniProtKBFintracellular ligand-gated calcium channel activity
GO:0035091 ISS:UniProtKBFphosphatidylinositol binding
GO:0007202 TAS:ReactomePactivation of phospholipase C activity
GO:0007596 TAS:ReactomePblood coagulation
GO:0006816 NAS:UniProtKBPcalcium ion transport
GO:0032469 IEA:EnsemblPendoplasmic reticulum calcium ion homeostasis
GO:0006112 TAS:ReactomePenergy reserve metabolic process
GO:0007173 TAS:ReactomePepidermal growth factor receptor signaling pathway
GO:0038095 TAS:ReactomePFc-epsilon receptor signaling pathway
GO:0038096 TAS:ReactomePFc-gamma receptor signaling pathway involved in phagocytosis
GO:0008543 TAS:ReactomePfibroblast growth factor receptor signaling pathway
GO:0045087 TAS:ReactomePinnate immune response
GO:0048016 ISS:GOCPinositol phosphate-mediated signaling
GO:0070059 ISS:UniProtKBPintrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:0050849 IDA:GO_CentralPnegative regulation of calcium-mediated signaling
GO:0048011 TAS:ReactomePneurotrophin TRK receptor signaling pathway
GO:0030168 TAS:ReactomePplatelet activation
GO:0009791 IEA:EnsemblPpost-embryonic development
GO:0050796 TAS:ReactomePregulation of insulin secretion
GO:0051209 ISS:UniProtKBPrelease of sequestered calcium ion into cytosol
GO:0001666 IDA:BHF-UCLPresponse to hypoxia
GO:0007165 NAS:UniProtKBPsignal transduction
GO:0044281 TAS:ReactomePsmall molecule metabolic process
GO:0050882 IEA:EnsemblPvoluntary musculoskeletal movement
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_75774Adaptive Immune System
REACT_118700Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
REACT_264224beta-catenin independent WNT signaling
REACT_263982Ca2+ pathway
REACT_23767cGMP effects
REACT_111064DAG and IP3 signaling
REACT_147694DAP12 interactions
REACT_147814DAP12 signaling
REACT_116125Disease
REACT_21272Downstream signaling of activated FGFR
REACT_17025Downstream signal transduction
REACT_2202Effects of PIP2 hydrolysis
REACT_12478EGFR interacts with phospholipase C-gamma
REACT_162Elevation of cytosolic Ca2+ levels
REACT_163936Fc epsilon receptor (FCERI) signaling
REACT_163834FCERI mediated Ca+2 mobilization
REACT_160123Fcgamma receptor (FCGR) dependent phagocytosis
REACT_18283G alpha (q) signalling events
REACT_120966Gastrin-CREB signalling pathway via PKC and MAPK
REACT_18274Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
REACT_19184GPCR downstream signaling
REACT_15526G-protein mediated events
REACT_604Hemostasis
REACT_6900Immune System
REACT_6802Innate Immune System
REACT_1505Integration of energy metabolism
REACT_111217Metabolism
REACT_12056NGF signalling via TRKA from the plasma membrane
REACT_23862Nitric oxide stimulates guanylate cyclase
REACT_15295Opioid Signalling
REACT_21310Phospholipase C-mediated cascade
REACT_798Platelet activation, signaling and aggregation
REACT_23905Platelet calcium homeostasis
REACT_23876Platelet homeostasis
REACT_15426PLC beta mediated events
REACT_115720PLCG1 events in ERBB2 signaling
REACT_12079PLC-gamma1 signalling
REACT_18325Regulation of insulin secretion
REACT_160158Role of phospholipids in phagocytosis
REACT_9417Signaling by EGFR
REACT_115871Signaling by EGFR in Cancer
REACT_268269Signaling by EGFRvIII in Cancer
REACT_115755Signaling by ERBB2
REACT_9470Signaling by FGFR
REACT_120736Signaling by FGFR in disease
REACT_14797Signaling by GPCR
REACT_268006Signaling by Ligand-Responsive EGFR Variants in Cancer
REACT_268546Signaling by Overexpressed Wild-Type EGFR in Cancer
REACT_16888Signaling by PDGF
REACT_118773Signaling by the B Cell Receptor (BCR)
REACT_12529Signaling by VEGF
REACT_11045Signaling by Wnt
REACT_11061Signalling by NGF
REACT_111102Signal Transduction
REACT_264464VEGFA-VEGFR2 Pathway
REACT_264273VEGFR2 mediated cell proliferation
SMP Pathway Links
SMP IDDescription
SMP00296Acebutolol Action Pathway
SMP00297Alprenolol Action Pathway
SMP00665Amiodarone Action Pathway
SMP00376Amlodipine Action Pathway
SMP00664Arbutamine Action Pathway
SMP00298Atenolol Action Pathway
SMP00299Betaxolol Action Pathway
SMP00668Bevantolol Action Pathway
SMP00300Bisoprolol Action Pathway
SMP00657Bopindolol Action Pathway
SMP00670Bupranolol Action Pathway
SMP00658Carteolol Action Pathway
SMP00367Carvedilol Action Pathway
SMP00359Diltiazem Action Pathway
SMP00325Disopyramide Action Pathway
SMP00662Dobutamine Action Pathway
SMP00661Epinephrine Action Pathway
SMP00301Esmolol Action Pathway
SMP00377Felodipine Action Pathway
SMP00331Flecainide Action Pathway
SMP00326Fosphenytoin (Antiarrhythmic) Action Pathway
SMP00332Ibutilide Action Pathway
SMP00663Isoprenaline Action Pathway
SMP00378Isradipine Action Pathway
SMP00368Labetalol Action Pathway
SMP00666Levobunolol Action Pathway
SMP00328Lidocaine (Antiarrhythmic) Action Pathway
SMP00667Metipranolol Action Pathway
SMP00302Metoprolol Action Pathway
SMP00329Mexiletine Action Pathway
SMP00588Muscle/Heart Contraction
SMP00303Nadolol Action Pathway
SMP00366Nebivolol Action Pathway
SMP00379Nifedipine Action Pathway
SMP00380Nimodipine Action Pathway
SMP00381Nisoldipine Action Pathway
SMP00382Nitrendipine Action Pathway
SMP00304Oxprenolol Action Pathway
SMP00305Penbutolol Action Pathway
SMP00327Phenytoin (Antiarrhythmic) Action Pathway
SMP00306Pindolol Action Pathway
SMP00669Practolol Action Pathway
SMP00324Procainamide (Antiarrhythmic) Action Pathway
SMP00307Propranolol Action Pathway
SMP00323Quinidine Action Pathway
SMP00660Sotalol Action Pathway
SMP00659Timolol Action Pathway
SMP00330Tocainide Action Pathway
SMP00375Verapamil Action Pathway
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