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MGP001696

UniProt Annotations

Entry Information
Gene Namejun B proto-oncogene
Protein EntryJUNB_HUMAN
UniProt IDP17275
SpeciesHuman
Comments
Comment typeDescription
FunctionTranscription factor involved in regulating gene activity following the primary growth factor response. Binds to the DNA sequence 5'-TGA[CG]TCA-3'.
InductionBy growth factors.
InteractionQ8N1L9:BATF2; NbExp=3; IntAct=EBI-748062, EBI-742695; Q86XI8:C19orf68; NbExp=2; IntAct=EBI-748062, EBI-2682158; P01100:FOS; NbExp=3; IntAct=EBI-748062, EBI-852851;
PtmUbiquitinated by ITCH, leading to its degradation. {ECO:0000269|PubMed:16387660}.
SimilarityBelongs to the bZIP family. Jun subfamily. {ECO:0000305}.
SimilarityContains 1 bZIP (basic-leucine zipper) domain. {ECO:0000255|PROSITE-ProRule:PRU00978}.
Subcellular LocationNucleus.
SubunitBinds DNA as a homodimer or as a heterodimer with another member of the Jun/Fos family. Interacts with ITCH (via its WW domains). {ECO:0000269|PubMed:16387660}.
Web ResourceName=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/JUNBID178.html";
Web ResourceName=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/junb/";
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