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MGP001706

Record overview

MGPD IDMGP001706
Gene ID3744
SpeciesHomo sapiens (Human)
Gene Namepotassium channel, voltage gated shaker related subfamily A, member 10
Gene Symbol KCNA10
SynonymsKcn1; Kv1.8;
Alternate namespotassium voltage-gated channel subfamily A member 10; cyclic GMP gated potassium channel; potassium voltage-gated channel, shaker-related subfamily, member 10; voltage-gated potassium channel subunit Kv1.8;
Chromosome1
Map Location1p13.1
SummaryPotassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It is specifically regulated by cGMP and postulated to mediate the effects of substances that increase intracellular cGMP. This gene is intronless, and the gene is clustered with genes KCNA2 and KCNA3 on chromosome 1. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for KCNA10

Proteins

potassium voltage-gated channel subfamily A member 10
Refseq ID:NP_005540
Protein GI:5031819
UniProt ID:Q16322
mRNA ID:NM_005549
Length:511
RefSeq Status:
MDVCGWKEMEVALVNFDNSDEIQEEPGYATDFDSTSPKGRPGGSSFSNGKILISESTNHETAFSKLPGDYADPPGPEPVVLNEGNQRVIINIAGLRFETQ
LRTLSQFPETLLGDREKRMQFFDSMRNEYFFDRNRPSFDGILYYYQSGGKIRRPANVPIDIFADEISFYELGSEAMDQFREDEGFIKDPETLLPTNDIHR
QFWLLFEYPESSSAARAVAVVSVLVVVISITIFCLETLPEFREDRELKVVRDPNLNMSKTVLSQTMFTDPFFMVESTCIVWFTFELVLRFVVCPSKTDFF
RNIMNIIDIISIIPYFATLITELVQETEPSAQQNMSLAILRIIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAEVDE
PESHFSSIPDGFWWAVVTMTTVGYGDMCPTTPGGKIVGTLCAIAGVLTIALPVPVIVSNFNYFYHRETENEEKQNIPGEIERILNSVGSRMGSTDSLNKT
NGGCSTEKSRK
 
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