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MGP001714

Record overview

MGPD IDMGP001714
Gene ID3752
SpeciesHomo sapiens (Human)
Gene Namepotassium channel, voltage gated Shal related subfamily D, member 3
Gene Symbol KCND3
SynonymsKV4.3; SCA19; SCA22; KCND3L; KCND3S; KSHIVB;
Alternate namespotassium voltage-gated channel subfamily D member 3; potassium ionic channel Kv4.3; potassium voltage-gated channel, Shal-related subfamily, member 3; sha1-related potassium channel Kv4.3; voltage-gated K+ channel; voltage-gated potassium channel subunit Kv4.3;
Chromosome1
Map Location1p13.3
SummaryVoltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shal-related subfamily, members of which form voltage-activated A-type potassium ion channels and are prominent in the repolarization phase of the action potential. This member includes two isoforms with different sizes, which are encoded by alternatively spliced transcript variants of this gene. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for KCND3

Proteins

potassium voltage-gated channel subfamily D member 3 isoform 1 precursor
Refseq ID:NP_004971
Protein GI:27436984
UniProt ID:Q9UK17
mRNA ID:NM_004980
Length:655
RefSeq Status:
MAAGVAAWLPFARAAAIGWMPVANCPMPLAPADKNKRQDELIVLNVSGRRFQTWRTTLERYPDTLLGSTEKEFFFNEDTKEYFFDRDPEVFRCVLNFYRT
GKLHYPRYECISAYDDELAFYGILPEIIGDCCYEEYKDRKRENAERLMDDNDSENNQESMPSLSFRQTMWRAFENPHTSTLALVFYYVTGFFIAVSVITN
VVETVPCGTVPGSKELPCGERYSVAFFCLDTACVMIFTVEYLLRLFAAPSRYRFIRSVMSIIDVVAIMPYYIGLVMTNNEDVSGAFVTLRVFRVFRIFKF
SRHSQGLRILGYTLKSCASELGFLLFSLTMAIIIFATVMFYAEKGSSASKFTSIPASFWYTIVTMTTLGYGDMVPKTIAGKIFGSICSLSGVLVIALPVP
VIVSNFSRIYHQNQRADKRRAQKKARLARIRVAKTGSSNAYLHSKRNGLLNEALELTGTPEEEHMGKTTSLIESQHHHLLHCLEKTTGLSYLVDDPLLSV
RTSTIKNHEFIDEQMFEQNCMESSMQNYPSTRSPSLSSHPGLTTTCCSRRSKKTTHLPNSNLPATRLRSMQELSTIHIQGSEQPSLTTSRSSLNLKADDG
LRPNCKTSQITTAIISIPTPPALTPEGESRPPPASPGPNTNIPSIASNVVKVSAL
 
sig_peptide: 1..16
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 1574
peptide sequence: 
MAAGVAAWLPFARAAA
 
potassium voltage-gated channel subfamily D member 3 isoform 2 precursor
Refseq ID:NP_751948
Protein GI:27436986
UniProt ID:Q9UK17
mRNA ID:NM_172198
Length:636
RefSeq Status:
MAAGVAAWLPFARAAAIGWMPVANCPMPLAPADKNKRQDELIVLNVSGRRFQTWRTTLERYPDTLLGSTEKEFFFNEDTKEYFFDRDPEVFRCVLNFYRT
GKLHYPRYECISAYDDELAFYGILPEIIGDCCYEEYKDRKRENAERLMDDNDSENNQESMPSLSFRQTMWRAFENPHTSTLALVFYYVTGFFIAVSVITN
VVETVPCGTVPGSKELPCGERYSVAFFCLDTACVMIFTVEYLLRLFAAPSRYRFIRSVMSIIDVVAIMPYYIGLVMTNNEDVSGAFVTLRVFRVFRIFKF
SRHSQGLRILGYTLKSCASELGFLLFSLTMAIIIFATVMFYAEKGSSASKFTSIPASFWYTIVTMTTLGYGDMVPKTIAGKIFGSICSLSGVLVIALPVP
VIVSNFSRIYHQNQRADKRRAQKKARLARIRVAKTGSSNAYLHSKRNGLLNEALELTGTPEEEHMGKTTSLIESQHHHLLHCLEKTTNHEFIDEQMFEQN
CMESSMQNYPSTRSPSLSSHPGLTTTCCSRRSKKTTHLPNSNLPATRLRSMQELSTIHIQGSEQPSLTTSRSSLNLKADDGLRPNCKTSQITTAIISIPT
PPALTPEGESRPPPASPGPNTNIPSIASNVVKVSAL
 
sig_peptide: 1..16
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 1574
peptide sequence: 
MAAGVAAWLPFARAAA

sig_peptide: 1..16
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 1574
peptide sequence: 
MAAGVAAWLPFARAAA
 
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