MGP Database

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MGP001718

Ontology/Pathway Information

Entrez Gene ID3757
Gene Namepotassium channel, voltage gated eag related subfamily H, member 2
Gene Symbol KCNH2
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0009986 IDA:BHF-UCLCcell surface
GO:0005737 IEA:EnsemblCcytoplasm
GO:0005635 IEA:EnsemblCnuclear envelope
GO:0005886 IDA:BHF-UCLCplasma membrane
GO:0008076 IDA:BHF-UCLCvoltage-gated potassium channel complex
GO:0005251 IDA:BHF-UCLFdelayed rectifier potassium channel activity
GO:0042802 IPI:IntActFidentical protein binding
GO:0005242 IDA:BHF-UCLFinward rectifier potassium channel activity
GO:0000155 IEA:InterProFphosphorelay sensor kinase activity
GO:0042803 IPI:BHF-UCLFprotein homodimerization activity
GO:0097110 IPI:BHF-UCLFscaffold protein binding
GO:0031625 IPI:BHF-UCLFubiquitin protein ligase binding
GO:0005249 IDA:BHF-UCLFvoltage-gated potassium channel activity
GO:1902282 IMP:BHF-UCLFvoltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization
GO:0060048 IMP:BHF-UCLPcardiac muscle contraction
GO:0035690 IDA:BHF-UCLPcellular response to drug
GO:0086010 IDA:BHF-UCLPmembrane depolarization during action potential
GO:0086011 IDA:BHF-UCLPmembrane repolarization during action potential
GO:0086013 IMP:BHF-UCLPmembrane repolarization during cardiac muscle cell action potential
GO:1902303 IDA:BHF-UCLPnegative regulation of potassium ion export
GO:1901380 IDA:BHF-UCLPnegative regulation of potassium ion transmembrane transport
GO:1901381 IDA:BHF-UCLPpositive regulation of potassium ion transmembrane transport
GO:0071435 IDA:BHF-UCLPpotassium ion export
GO:0055075 IDA:BHF-UCLPpotassium ion homeostasis
GO:0071805 IDA:BHF-UCLPpotassium ion transmembrane transport
GO:0086091 IMP:BHF-UCLPregulation of heart rate by cardiac conduction
GO:0003064 TAS:BHF-UCLPregulation of heart rate by hormone
GO:0042391 IDA:BHF-UCLPregulation of membrane potential
GO:0060306 IDA:BHF-UCLPregulation of membrane repolarization
GO:1901379 IDA:BHF-UCLPregulation of potassium ion transmembrane transport
GO:0060307 IMP:BHF-UCLPregulation of ventricular cardiac muscle cell membrane repolarization
GO:0007268 TAS:ReactomePsynaptic transmission
GO:0086005 IMP:BHF-UCLPventricular cardiac muscle cell action potential
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_13685Neuronal System
REACT_75908Potassium Channels
REACT_75770Voltage gated Potassium channels
SMP Pathway Links
SMP IDDescription
SMP00296Acebutolol Action Pathway
SMP00297Alprenolol Action Pathway
SMP00665Amiodarone Action Pathway
SMP00376Amlodipine Action Pathway
SMP00664Arbutamine Action Pathway
SMP00298Atenolol Action Pathway
SMP00299Betaxolol Action Pathway
SMP00668Bevantolol Action Pathway
SMP00300Bisoprolol Action Pathway
SMP00657Bopindolol Action Pathway
SMP00670Bupranolol Action Pathway
SMP00658Carteolol Action Pathway
SMP00367Carvedilol Action Pathway
SMP00359Diltiazem Action Pathway
SMP00325Disopyramide Action Pathway
SMP00662Dobutamine Action Pathway
SMP00661Epinephrine Action Pathway
SMP00301Esmolol Action Pathway
SMP00377Felodipine Action Pathway
SMP00331Flecainide Action Pathway
SMP00326Fosphenytoin (Antiarrhythmic) Action Pathway
SMP00332Ibutilide Action Pathway
SMP00663Isoprenaline Action Pathway
SMP00378Isradipine Action Pathway
SMP00368Labetalol Action Pathway
SMP00666Levobunolol Action Pathway
SMP00328Lidocaine (Antiarrhythmic) Action Pathway
SMP00667Metipranolol Action Pathway
SMP00302Metoprolol Action Pathway
SMP00329Mexiletine Action Pathway
SMP00588Muscle/Heart Contraction
SMP00303Nadolol Action Pathway
SMP00366Nebivolol Action Pathway
SMP00379Nifedipine Action Pathway
SMP00380Nimodipine Action Pathway
SMP00381Nisoldipine Action Pathway
SMP00382Nitrendipine Action Pathway
SMP00304Oxprenolol Action Pathway
SMP00305Penbutolol Action Pathway
SMP00327Phenytoin (Antiarrhythmic) Action Pathway
SMP00306Pindolol Action Pathway
SMP00669Practolol Action Pathway
SMP00324Procainamide (Antiarrhythmic) Action Pathway
SMP00307Propranolol Action Pathway
SMP00323Quinidine Action Pathway
SMP00660Sotalol Action Pathway
SMP00659Timolol Action Pathway
SMP00330Tocainide Action Pathway
SMP00375Verapamil Action Pathway
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