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MGP001732

UniProt Annotations

Entry Information
Gene Namepotassium channel, inwardly rectifying subfamily J, member 16
Protein EntryKCJ16_HUMAN
UniProt IDQ9NPI9
SpeciesHuman
Comments
Comment typeDescription
FunctionInward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. KCNJ16 may be involved in the regulation of fluid and pH balance.
SimilarityBelongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ16 subfamily. {ECO:0000305}.
Subcellular LocationMembrane; Multi-pass membrane protein.
SubunitSeems to form heterodimer with Kir4.1/KCNJ10 or Kir2.1/KCNJ2.
Tissue SpecificityHighly expressed in kidney, pancreas and thyroid gland.
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