MGP Database

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MGP001733

UniProt Annotations

Entry Information
Gene Namepotassium channel, two pore domain subfamily K, member 1
Protein EntryKCNK1_HUMAN
UniProt IDO00180
SpeciesHuman
Comments
Comment typeDescription
FunctionWeakly inward rectifying potassium channel. {ECO:0000269|PubMed:8605869}.
MiscellaneousInhibited by barium, quinine, quinidine and internal acidification. Activated by protein kinase C.
SimilarityBelongs to the two pore domain potassium channel (TC 1.A.1.8) family. {ECO:0000305}.
Subcellular LocationMembrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
SubunitHomodimer; disulfide-linked. {ECO:0000269|PubMed:22282804}.
Tissue SpecificityWidely expressed with high levels in heart and brain and lower levels in placenta, lung, liver and kidney.
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