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MGP001735

Record overview

MGPD IDMGP001735
Gene ID3777
SpeciesHomo sapiens (Human)
Gene Namepotassium channel, two pore domain subfamily K, member 3
Gene Symbol KCNK3
SynonymsOAT1; PPH4; TASK; TBAK1; K2p3.1; TASK-1;
Alternate namespotassium channel subfamily K member 3; TWIK-related acid-sensitive K(+) channel 1; TWIK-related acid-sensitive K+ channel; acid-sensitive potassium channel protein TASK; acid-sensitive potassium channel protein TASK-1; cardiac potassium channel; potassium inwardly-rectifying channel, subfamily K, member 3; two P domain potassium channel; two pore K(+) channel KT3.1; two pore potassium channel KT3.1;
Chromosome2
Map Location2p23
SummaryThis gene encodes a member of the superfamily of potassium channel proteins that contain two pore-forming P domains. The encoded protein is an outwardly rectifying channel that is sensitive to changes in extracellular pH and is inhibited by extracellular acidification. Also referred to as an acid-sensitive potassium channel, it is activated by the anesthetics halothane and isoflurane. Although three transcripts are detected in northern blots, there is currently no sequence available to confirm transcript variants for this gene. [provided by RefSeq, Aug 2008]
OrthologsView orthologs and multiple alignments for KCNK3

Proteins

potassium channel subfamily K member 3
Refseq ID:NP_002237
Protein GI:4504849
UniProt ID:O14649
mRNA ID:NM_002246
Length:394
RefSeq Status:
MKRQNVRTLALIVCTFTYLLVGAAVFDALESEPELIERQRLELRQQELRARYNLSQGGYEELERVVLRLKPHKAGVQWRFAGSFYFAITVITTIGYGHAA
PSTDGGKVFCMFYALLGIPLTLVMFQSLGERINTLVRYLLHRAKKGLGMRRADVSMANMVLIGFFSCISTLCIGAAAFSHYEHWTFFQAYYYCFITLTTI
GFGDYVALQKDQALQTQPQYVAFSFVYILTGLTVIGAFLNLVVLRFMTMNAEDEKRDAEHRALLTRNGQAGGGGGGGSAHTTDTASSTAAAGGGGFRNVY
AEVLHFQSMCSCLWYKSREKLQYSIPMIIPRDLSTSDTCVEQSHSSPGGGGRYSDTPSRRCLCSGAPRSAISSVSTGLHSLSTFRGLMKRRSSV
 
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