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MGP001738

Record overview

MGPD IDMGP001738
Gene ID3780
SpeciesHomo sapiens (Human)
Gene Namepotassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 1
Gene Symbol KCNN1
SynonymsSK1; hSK1; SKCA1; KCa2.1;
Alternate namessmall conductance calcium-activated potassium channel protein 1; potassium intermediate/small conductance calcium-activated channel, subfamily N, member 1; small conductance calcium-activated potassium channel 1;
Chromosome19
Map Location19p13.1
SummaryAction potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. The protein encoded by this gene is activated before membrane hyperpolarization and is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. The encoded protein is an integral membrane protein that forms a voltage-independent calcium-activated channel with three other calmodulin-binding subunits. This gene is a member of the KCNN family of potassium channel genes. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for KCNN1

Proteins

small conductance calcium-activated potassium channel protein 1
Refseq ID:NP_002239
Protein GI:25777643
UniProt ID:Q92952
mRNA ID:NM_002248
Length:543
RefSeq Status:
MNSHSYNGSVGRPLGSGPGALGRDPPDPEAGHPPQPPHSPGLQVVVAKSEPARPSPGSPRGQPQDQDDDEDDEEDEAGRQRASGKPSNVGHRLGHRRALF
EKRKRLSDYALIFGMFGIVVMVTETELSWGVYTKESLYSFALKCLISLSTAILLGLVVLYHAREIQLFMVDNGADDWRIAMTCERVFLISLELAVCAIHP
VPGHYRFTWTARLAFTYAPSVAEADVDVLLSIPMFLRLYLLGRVMLLHSKIFTDASSRSIGALNKITFNTRFVMKTLMTICPGTVLLVFSISSWIIAAWT
VRVCERYHDKQEVTSNFLGAMWLISITFLSIGYGDMVPHTYCGKGVCLLTGIMGAGCTALVVAVVARKLELTKAEKHVHNFMMDTQLTKRVKNAAANVLR
ETWLIYKHTRLVKKPDQARVRKHQRKFLQAIHQAQKLRSVKIEQGKLNDQANTLTDLAKTQTVMYDLVSELHAQHEELEARLATLESRLDALGASLQALP
GLIAQAIRPPPPPLPPRPGPGPQDQAARSSPCRWTPVAPSDCG
 
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