MGP Database

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MGP001753

UniProt Annotations

Entry Information
Gene Namekinesin family member 5B
Protein EntryKINH_HUMAN
UniProt IDP33176
SpeciesHuman
Comments
Comment typeDescription
DomainComposed of three structural domains: a large globular N- terminal domain which is responsible for the motor activity of kinesin (it hydrolyzes ATP and binds microtubule), a central alpha-helical coiled coil domain that mediates the heavy chain dimerization; and a small globular C-terminal domain which interacts with other proteins (such as the kinesin light chains), vesicles and membranous organelles.
FunctionMicrotubule-dependent motor required for normal distribution of mitochondria and lysosomes. {ECO:0000250}.
InteractionP68619:VACWR159 (xeno); NbExp=3; IntAct=EBI-355878, EBI-7133540;
SimilarityBelongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Kinesin subfamily. {ECO:0000255|PROSITE-ProRule:PRU00283}.
SimilarityContains 1 kinesin motor domain. {ECO:0000255|PROSITE- ProRule:PRU00283}.
Subcellular LocationCytoplasm, cytoskeleton {ECO:0000250}. Note=Uniformly distributed between soma and neurites in hippocampal neurons. {ECO:0000250}.
SubunitOligomer composed of two heavy chains and two light chains. Interacts with GRIP1 and PPP1R42 (By similarity). Interacts with SYBU. Interacts with JAKMIP1. Interacts with PLEKHM2. Interacts with ECM29. {ECO:0000250, ECO:0000269|PubMed:12368902, ECO:0000269|PubMed:15459722, ECO:0000269|PubMed:15905402, ECO:0000269|PubMed:17532644, ECO:0000269|PubMed:20682791, ECO:0000269|PubMed:8606779}.
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