MGP Database

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MGP001765

Ontology/Pathway Information

Entrez Gene ID3815
Gene Namev-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
Gene Symbol KIT
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0001669 IEA:EnsemblCacrosomal vesicle
GO:0005911 IEA:EnsemblCcell-cell junction
GO:0009898 IEA:EnsemblCcytoplasmic side of plasma membrane
GO:0009897 IEA:EnsemblCexternal side of plasma membrane
GO:0005615 IDA:BHF-UCLCextracellular space
GO:0016021 IEA:UniProtKB-KWCintegral component of membrane
GO:0042629 IMP:GOCCmast cell granule
GO:0005886 TAS:ReactomeCplasma membrane
GO:0005524 IEA:UniProtKB-KWFATP binding
GO:0019955 IDA:UniProtKBFcytokine binding
GO:0046872 IEA:UniProtKB-KWFmetal ion binding
GO:0042803 IPI:UniProtKBFprotein homodimerization activity
GO:0004713 TAS:ProtIncFprotein tyrosine kinase activity
GO:0004716 TAS:ProtIncFreceptor signaling protein tyrosine kinase activity
GO:0005020 IEA:EnsemblFstem cell factor receptor activity
GO:0004714 IDA:UniProtKBFtransmembrane receptor protein tyrosine kinase activity
GO:0031532 IDA:UniProtKBPactin cytoskeleton reorganization
GO:0000187 IDA:UniProtKBPactivation of MAPK activity
GO:0060326 IDA:UniProtKBPcell chemotaxis
GO:0097067 IEA:EnsemblPcellular response to thyroid hormone stimulus
GO:0019221 IDA:UniProtKBPcytokine-mediated signaling pathway
GO:0002371 ISS:UniProtKBPdendritic cell cytokine production
GO:0050910 ISS:UniProtKBPdetection of mechanical stimulus involved in sensory perception of sound
GO:0048565 ISS:UniProtKBPdigestive tract development
GO:0035234 IEA:EnsemblPectopic germ cell programmed cell death
GO:0035162 ISS:UniProtKBPembryonic hemopoiesis
GO:0007173 TAS:ReactomePepidermal growth factor receptor signaling pathway
GO:0050673 IEA:EnsemblPepithelial cell proliferation
GO:0030218 ISS:UniProtKBPerythrocyte differentiation
GO:0038162 ISS:UniProtKBPerythropoietin-mediated signaling pathway
GO:0038095 TAS:ReactomePFc-epsilon receptor signaling pathway
GO:0038093 IDA:UniProtKBPFc receptor signaling pathway
GO:0008543 TAS:ReactomePfibroblast growth factor receptor signaling pathway
GO:0008354 IEA:EnsemblPgerm cell migration
GO:0006687 IEA:EnsemblPglycosphingolipid metabolic process
GO:0030097 TAS:UniProtKBPhemopoiesis
GO:0002327 ISS:UniProtKBPimmature B cell differentiation
GO:0006954 ISS:UniProtKBPinflammatory response
GO:0045087 TAS:ReactomePinnate immune response
GO:0038109 IDA:UniProtKBPKit signaling pathway
GO:0030032 ISS:UniProtKBPlamellipodium assembly
GO:0002320 IEA:EnsemblPlymphoid progenitor cell differentiation
GO:0008584 IEP:UniProtKBPmale gonad development
GO:0002551 IDA:UniProtKBPmast cell chemotaxis
GO:0032762 IDA:UniProtKBPmast cell cytokine production
GO:0043303 IMP:UniProtKBPmast cell degranulation
GO:0060374 ISS:UniProtKBPmast cell differentiation
GO:0070662 TAS:UniProtKBPmast cell proliferation
GO:0035855 ISS:UniProtKBPmegakaryocyte development
GO:0097326 ISS:UniProtKBPmelanocyte adhesion
GO:0030318 ISS:UniProtKBPmelanocyte differentiation
GO:0097324 ISS:UniProtKBPmelanocyte migration
GO:0002318 IEA:EnsemblPmyeloid progenitor cell differentiation
GO:0043069 IEA:EnsemblPnegative regulation of programmed cell death
GO:0048011 TAS:ReactomePneurotrophin TRK receptor signaling pathway
GO:0001541 ISS:UniProtKBPovarian follicle development
GO:0018108 IDA:UniProtKBPpeptidyl-tyrosine phosphorylation
GO:0048015 TAS:ReactomePphosphatidylinositol-mediated signaling
GO:0043473 ISS:UniProtKBPpigmentation
GO:0030335 IEA:EnsemblPpositive regulation of cell migration
GO:0008284 IEA:EnsemblPpositive regulation of cell proliferation
GO:0010628 IEA:EnsemblPpositive regulation of gene expression
GO:0046427 IMP:UniProtKBPpositive regulation of JAK-STAT cascade
GO:0048170 IEA:EnsemblPpositive regulation of long-term neuronal synaptic plasticity
GO:0043410 IMP:UniProtKBPpositive regulation of MAPK cascade
GO:0045747 IEA:EnsemblPpositive regulation of Notch signaling pathway
GO:0043552 TAS:UniProtKBPpositive regulation of phosphatidylinositol 3-kinase activity
GO:0014068 TAS:UniProtKBPpositive regulation of phosphatidylinositol 3-kinase signaling
GO:0010863 TAS:UniProtKBPpositive regulation of phospholipase C activity
GO:0031274 IEA:EnsemblPpositive regulation of pseudopodium assembly
GO:0051091 IMP:UniProtKBPpositive regulation of sequence-specific DNA binding transcription factor activity
GO:0042511 IMP:UniProtKBPpositive regulation of tyrosine phosphorylation of Stat1 protein
GO:0042517 IMP:UniProtKBPpositive regulation of tyrosine phosphorylation of Stat3 protein
GO:0042523 IMP:UniProtKBPpositive regulation of tyrosine phosphorylation of Stat5 protein
GO:0046777 IDA:UniProtKBPprotein autophosphorylation
GO:0042127 TAS:UniProtKBPregulation of cell proliferation
GO:0008360 ISS:UniProtKBPregulation of cell shape
GO:0048070 IEA:EnsemblPregulation of developmental pigmentation
GO:0007165 TAS:ProtIncPsignal transduction
GO:0023014 TAS:GOCPsignal transduction by phosphorylation
GO:0048103 IEA:EnsemblPsomatic stem cell division
GO:0035019 IEA:EnsemblPsomatic stem cell maintenance
GO:0007286 IEA:EnsemblPspermatid development
GO:0007283 ISS:UniProtKBPspermatogenesis
GO:0048863 ISS:UniProtKBPstem cell differentiation
GO:0019827 TAS:UniProtKBPstem cell maintenance
GO:0030217 ISS:UniProtKBPT cell differentiation
GO:0008542 IEA:EnsemblPvisual learning
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_75774Adaptive Immune System
REACT_147727Constitutive PI3K/AKT Signaling in Cancer
REACT_147694DAP12 interactions
REACT_147814DAP12 signaling
REACT_116125Disease
REACT_118638Downstream signaling events of B Cell Receptor (BCR)
REACT_21272Downstream signaling of activated FGFR
REACT_17025Downstream signal transduction
REACT_163936Fc epsilon receptor (FCERI) signaling
REACT_12578GAB1 signalosome
REACT_6900Immune System
REACT_6802Innate Immune System
REACT_12056NGF signalling via TRKA from the plasma membrane
REACT_12464PI3K/AKT activation
REACT_147723PI3K/AKT Signaling in Cancer
REACT_21270PI-3K cascade
REACT_116008PI3K events in ERBB2 signaling
REACT_115961PI3K events in ERBB4 signaling
REACT_75829PIP3 activates AKT signaling
REACT_111225Regulation of KIT signaling
REACT_163769Role of LAT2/NTAL/LAB on calcium mobilization
REACT_9417Signaling by EGFR
REACT_115871Signaling by EGFR in Cancer
REACT_268269Signaling by EGFRvIII in Cancer
REACT_115755Signaling by ERBB2
REACT_115596Signaling by ERBB4
REACT_9470Signaling by FGFR
REACT_120736Signaling by FGFR in disease
REACT_268006Signaling by Ligand-Responsive EGFR Variants in Cancer
REACT_268546Signaling by Overexpressed Wild-Type EGFR in Cancer
REACT_16888Signaling by PDGF
REACT_111040Signaling by SCF-KIT
REACT_118773Signaling by the B Cell Receptor (BCR)
REACT_11061Signalling by NGF
REACT_111102Signal Transduction
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