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MGP001779

Record overview

MGPD IDMGP001779
Gene ID3838
SpeciesHomo sapiens (Human)
Gene Namekaryopherin alpha 2 (RAG cohort 1, importin alpha 1)
Gene Symbol KPNA2
SynonymsQIP2; RCH1; IPOA1; SRP1alpha;
Alternate namesimportin subunit alpha-1; RAG cohort 1; RAG cohort protein 1; SRP1-alpha; importin alpha 1; importin alpha 2; importin subunit alpha-2; importin-alpha-P1; karyopherin subunit alpha-2; pendulin;
Chromosome17
Map Location17q24.2
SummaryThe import of proteins into the nucleus is a process that involves at least 2 steps. The first is an energy-independent docking of the protein to the nuclear envelope and the second is an energy-dependent translocation through the nuclear pore complex. Imported proteins require a nuclear localization sequence (NLS) which generally consists of a short region of basic amino acids or 2 such regions spaced about 10 amino acids apart. Proteins involved in the first step of nuclear import have been identified in different systems. These include the Xenopus protein importin and its yeast homolog, SRP1 (a suppressor of certain temperature-sensitive mutations of RNA polymerase I in Saccharomyces cerevisiae), which bind to the NLS. KPNA2 protein interacts with the NLSs of DNA helicase Q1 and SV40 T antigen and may be involved in the nuclear transport of proteins. KPNA2 also may play a role in V(D)J recombination [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for KPNA2

Proteins

importin subunit alpha-1
Refseq ID:NP_002257
Protein GI:4504897
UniProt ID:P52292
mRNA ID:NM_002266
Length:529
RefSeq Status:
MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAA
RKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLV
IKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVK
LLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWA
VTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEE
EEDQNVVPETTSEGYTFQVQDGAPGTFNF
 
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