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MGP001784

UniProt Annotations

Entry Information
Gene Nameimportin 5
Protein EntryIPO5_HUMAN
UniProt IDO00410
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=3; Name=1; IsoId=O00410-1; Sequence=Displayed; Name=2; IsoId=O00410-2; Sequence=VSP_037587; Name=3; IsoId=O00410-3; Sequence=VSP_037774; Note=Ref.2 (CAA70103) sequence differs from that shown due to a frameshift in position 18. {ECO:0000305};
FunctionFunctions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5. Binds to a beta-like import receptor binding (BIB) domain of RPL23A. In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones. In case of HIV-1 infection, binds and mediates the nuclear import of HIV-1 Rev. {ECO:0000250, ECO:0000269|PubMed:9687515}.
InteractionP27958:- (xeno); NbExp=5; IntAct=EBI-356424, EBI-8753518; O95166:GABARAP; NbExp=6; IntAct=EBI-356424, EBI-712001; Q9H0R8:GABARAPL1; NbExp=4; IntAct=EBI-356424, EBI-746969; P60520:GABARAPL2; NbExp=5; IntAct=EBI-356424, EBI-720116; Q9GZQ8:MAP1LC3B; NbExp=2; IntAct=EBI-356424, EBI-373144; Q9BXW4:MAP1LC3C; NbExp=2; IntAct=EBI-356424, EBI-2603996; P18124:RPL7; NbExp=4; IntAct=EBI-356424, EBI-350806;
Sequence CautionSequence=CAA70103.1; Type=Frameshift; Positions=18; Evidence={ECO:0000305};
SimilarityBelongs to the importin beta family. Importin beta-3 subfamily. {ECO:0000305}.
SimilarityContains 1 importin N-terminal domain. {ECO:0000255|PROSITE-ProRule:PRU00115}.
SimilarityContains 24 HEAT repeats. {ECO:0000250|UniProtKB:P32337, ECO:0000305|PubMed:23541588}.
Subcellular LocationCytoplasm. Nucleus. Nucleus, nucleolus. Note=Nucleus; nuclear rim. Found particularly in the nuclear rim and nucleolus.
SubunitBinds RPL23A, RPS7 and RPL5. Interacts with H2A, H2B, H3 and H4 histones (By similarity). Binds to HIV-1 Rev. {ECO:0000250, ECO:0000269|PubMed:16704975, ECO:0000269|PubMed:9687515}.
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