MGP Database

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MGP001796

UniProt Annotations

Entry Information
Gene Namelaminin, gamma 1 (formerly LAMB2)
Protein EntryLAMC1_HUMAN
UniProt IDP11047
SpeciesHuman
Comments
Comment typeDescription
DomainDomains VI and IV are globular.
DomainThe alpha-helical domains I and II are thought to interact with other laminin chains to form a coiled coil structure.
FunctionBinding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.
SimilarityContains 11 laminin EGF-like domains. {ECO:0000255|PROSITE-ProRule:PRU00460}.
SimilarityContains 1 laminin IV type A domain. {ECO:0000255|PROSITE-ProRule:PRU00458}.
SimilarityContains 1 laminin N-terminal domain. {ECO:0000255|PROSITE-ProRule:PRU00466}.
Subcellular LocationSecreted, extracellular space, extracellular matrix, basement membrane.
SubunitLaminin is a complex glycoprotein, consisting of three different polypeptide chains (alpha, beta, gamma), which are bound to each other by disulfide bonds into a cross-shaped molecule comprising one long and three short arms with globules at each end. Gamma-1 is a subunit of laminin-1 (laminin-111 or EHS laminin), laminin-2 (laminin-211 or merosin), laminin-3 (laminin- 121 or S-laminin), laminin-4 (laminin-221 or S-merosin), laminin-6 (laminin-311 or K-laminin), laminin-7 (laminin-321 or KS-laminin), laminin-8 (laminin-411), laminin-9 (laminin-421), laminin-10 (laminin-511) and laminin-11 (laminin-521).
Tissue SpecificityFound in the basement membranes (major component).
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