MGP Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
MGP001800

UniProt Annotations

Entry Information
Gene Namelipopolysaccharide binding protein
Protein EntryLBP_HUMAN
UniProt IDP18428
SpeciesHuman
Comments
Comment typeDescription
FunctionPlays a role in the innate immune response. Binds to the lipid A moiety of bacterial lipopolysaccharides (LPS), a glycolipid present in the outer membrane of all Gram-negative bacteria, and acts as an affinity enhancer for CD14, facilitating its association with LPS. Promotes the release of cytokines in response to bacterial lipopolysaccharide. {ECO:0000269|PubMed:17481951, ECO:0000269|PubMed:24120359}.
InteractionQ13162:PRDX4; NbExp=4; IntAct=EBI-3927059, EBI-2211957;
SimilarityBelongs to the BPI/LBP/Plunc superfamily. BPI/LBP family. {ECO:0000305}.
Subcellular LocationSecreted {ECO:0000269|PubMed:24120359}.
SubunitWhen bound to LPS, interacts (via C-terminus) with soluble CD14. {ECO:0000269|PubMed:17481951}.
Tissue SpecificityDetected in blood serum (at protein level). {ECO:0000269|PubMed:24120359}.
  logo