MGP Database

MGP001802

Record overview

MGPD ID	MGP001802
Gene ID	3931
Species	Homo sapiens (Human)
Gene Name	lecithin-cholesterol acyltransferase
Gene Symbol	LCAT
Alternate names	phosphatidylcholine-sterol acyltransferase; phospholipid-cholesterol acyltransferase;
Chromosome	16
Map Location	16q22.1
EC Number	2.3.1.43
Summary	This gene encodes the extracellular cholesterol esterifying enzyme, lecithin-cholesterol acyltransferase. The esterification of cholesterol is required for cholesterol transport. Mutations in this gene have been found to cause fish-eye disease as well as LCAT deficiency. [provided by RefSeq, Jul 2008]
Orthologs	View orthologs and multiple alignments for LCAT

Proteins

phosphatidylcholine-sterol acyltransferase precursor

Refseq ID:	NP_000220
Protein GI:	4557892
UniProt ID:	P04180
mRNA ID:	NM_000229
Length:	440
RefSeq Status:

MGPPGSPWQWVTLLLGLLLPPAAPFWLLNVLFPPHTTPKAELSNHTRPVILVPGCLGNQLEAKLDKPDVVNWMCYRKTEDFFTIWLDLNMFLPLGVDCWI
DNTRVVYNRSSGLVSNAPGVQIRVPGFGKTYSVEYLDSSKLAGYLHTLVQNLVNNGYVRDETVRAAPYDWRLEPGQQEEYYRKLAGLVEEMHAAYGKPVF
LIGHSLGCLHLLYFLLRQPQAWKDRFIDGFISLGAPWGGSIKPMLVLASGDNQGIPIMSSIKLKEEQRITTTSPWMFPSRMAWPEDHVFISTPSFNYTGR
DFQRFFADLHFEEGWYMWLQSRDLLAGLPAPGVEVYCLYGVGLPTPRTYIYDHGFPYTDPVGVLYEDGDDTVATRSTELCGLWQGRQPQPVHLLPLHGIQ
HLNMVFSNLTLEHINAILLGAYRQGPPASPTASPEPPPPE

sig_peptide: 1..24
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2512
peptide sequence: 
MGPPGSPWQWVTLLLGLLLPPAAP

mat_peptide: 25..440
product: phosphatidylcholine-sterol acyltransferase
calculated_mol_wt: 47084
peptide sequence: 
FWLLNVLFPPHTTPKAELSNHTRPVILVPGCLGNQLEAKLDKPDVVNWMCYRKTEDFFTIWLDLNMFLPLGVDCWIDNTRVVYNRSSGLVSNAPGVQIRV
PGFGKTYSVEYLDSSKLAGYLHTLVQNLVNNGYVRDETVRAAPYDWRLEPGQQEEYYRKLAGLVEEMHAAYGKPVFLIGHSLGCLHLLYFLLRQPQAWKD
RFIDGFISLGAPWGGSIKPMLVLASGDNQGIPIMSSIKLKEEQRITTTSPWMFPSRMAWPEDHVFISTPSFNYTGRDFQRFFADLHFEEGWYMWLQSRDL
LAGLPAPGVEVYCLYGVGLPTPRTYIYDHGFPYTDPVGVLYEDGDDTVATRSTELCGLWQGRQPQPVHLLPLHGIQHLNMVFSNLTLEHINAILLGAYRQ
GPPASPTASPEPPPPE