MGP Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
MGP001808

UniProt Annotations

Entry Information
Gene Namelactate dehydrogenase A
Protein EntryLDHA_HUMAN
UniProt IDP00338
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=5; Name=1; IsoId=P00338-1; Sequence=Displayed; Name=2; IsoId=P00338-2; Sequence=VSP_014261, VSP_042787; Note=No experimental confirmation available.; Name=3; IsoId=P00338-3; Sequence=VSP_042206; Name=4; IsoId=P00338-4; Sequence=VSP_042786; Name=5; IsoId=P00338-5; Sequence=VSP_042788, VSP_042789;
Catalytic Activity(S)-lactate + NAD(+) = pyruvate + NADH.
DiseaseGlycogen storage disease 11 (GSD11) [MIM:612933]: A metabolic disorder that results in exertional myoglobinuria, pain, cramps and easy fatigue. {ECO:0000269|PubMed:2334430}. Note=The disease is caused by mutations affecting the gene represented in this entry.
InteractionP11142:HSPA8; NbExp=4; IntAct=EBI-372327, EBI-351896;
PathwayFermentation; pyruvate fermentation to lactate; (S)- lactate from pyruvate: step 1/1.
PtmISGylated. {ECO:0000269|PubMed:16139798}.
SimilarityBelongs to the LDH/MDH superfamily. LDH family. {ECO:0000305}.
Subcellular LocationCytoplasm.
SubunitHomotetramer. {ECO:0000269|PubMed:11276087}.
Web ResourceName=Protein Spotlight; Note=Another dark horse - Issue 109 of September 2009; URL="http://web.expasy.org/spotlight/back_issues/109";
Web ResourceName=Wikipedia; Note=Lactate dehydrogenase entry; URL="http://en.wikipedia.org/wiki/Lactate_dehydrogenase";
  logo